四步全合成卷柏素 D
Four-Step Total Synthesis of Selaginpulvilin D.
机构信息
Research School of Chemistry, Australian National University , Canberra, ACT 2601, Australia.
出版信息
Org Lett. 2017 Feb 3;19(3):636-637. doi: 10.1021/acs.orglett.6b03793. Epub 2017 Jan 17.
PMID:28094963
Abstract
An extremely concise total synthesis of a potent phosphodiesterase-4 inhibitory natural product, selaginpulvilin D, is reported. The synthesis features a one-pot, 3-fold electrophilic aromatic substitution sequence to assemble a 9,9-diarylfluorene core. The approach allows access to useful quantities of a selaginpulvilin natural product for the first time.
摘要
报道了一种强效磷酸二酯酶-4 抑制天然产物，即塞拉京 Pulvilin D 的极其简洁的全合成。该合成的特点是一锅三步亲电芳香取代序列，用于组装 9,9-二芳基芴核心。该方法首次为塞拉京 Pulvilin 天然产物的大量获得提供了途径。
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