Zhang Yang, Wang Jing
.
Biol Chem. 2017 Jul 26;398(8):929-938. doi: 10.1515/hsz-2016-0308.
Despite of continuous development of cancer treatment over the past decades, drug resistance is still one of the major hurdles of effective therapy for advanced colorectal cancer (CRC) worldwide and the understanding of its underlying mechanisms remains limited. Data which have emerged suggests that many microRNAs (miRNAs) may contribute to drug resistance in CRC. Major findings on miRNA functions in drug resistance of CRC are systemically reviewed here, with the goal of providing new updates to broaden our comprehension of its mechanisms and evidence to utilize miRNAs as potential therapeutic targets for CRC treatment.
尽管在过去几十年中癌症治疗不断发展，但耐药性仍是全球晚期结直肠癌（CRC）有效治疗的主要障碍之一，对其潜在机制的了解仍然有限。已出现的数据表明，许多微小RNA（miRNA）可能与CRC的耐药性有关。本文系统综述了miRNA在CRC耐药中的主要功能研究结果，目的是提供新的进展，以拓宽我们对其机制的理解，并为将miRNA用作CRC治疗的潜在靶点提供依据。
