Saluja Raminder
J Drugs Dermatol. 2016 Nov 1;15(11):1398-1401.
The diffractive optic coupled with a picosecond pulsed alexandrite laser has been shown to effectively minimize pigmen- tation while improving the appearance of textural irregularities and rhytides. We evaluated the safety and ef cacy of the diffractive optic laser treatment for off of the face applications including the hands and décolletage in a pico-toning technique.
20 healthy female patients (40-70 years of age) were treated with a picosecond pulsed alexandrite laser with a diffractive lens. 10 of the patients were enrolled in a prospective hand assessment study (20 hands) while the remaining 10 subjects were enrolled in an IRB approved study treating photodamage of the décolletage. Protocol for both groups included 4 treatments to the designated area with a picopulsed alexandrite laser with a diffractive lens on a 6mm handpiece delivering 0.71 j/cm2 with 10 hz repetition at 3 week intervals (+- 7 days) with follow up at 1 month and 3 months post fourth treatment using standardized digital photography.
Statistically signi cant improvement in the overall appearance of pigmentation, texture and rhytides were recorded at each sub- sequent visit and at 1 and 3 months post the nal laser treatment. Clinical photographs were evaluated from baseline to the final photo at 3 months post last laser treatment by the treating physician, patient, and an independent evaluator. All hand subjects and chest subjects showed improvement in all 3 areas which were found to be statistically signi cant. No adverse events occurred in either study group.
These study results show signi cant improvement in not only pigmentation, but in texture and rhytides in all subjects receiving pico-toning laser treatments to off of the face areas. The laser was well tolerated by all patients with no adverse effects. The use of a diffractive lens optic on a 6 mm xed spot size handpiece with a picopulsed alexandrite laser, in a pico-toning technique, provides a safe, low uence, yet effective treatment for not only pigment dyschromia but also textural irregularities and rhytides when treating the hands and décolletage. J Drugs Dermatol. 2016;15(11):1398-1401..
已证明，衍射光学元件与皮秒脉冲紫翠宝石激光相结合，可有效减少色素沉着，同时改善质地不均和皱纹外观。我们评估了衍射光学激光治疗在皮秒嫩肤技术中对面部以外部位（包括手部和颈部）应用的安全性和有效性。
20名健康女性患者（40 - 70岁）接受了带有衍射透镜的皮秒脉冲紫翠宝石激光治疗。其中10名患者参与了一项前瞻性手部评估研究（20只手），其余10名受试者参与了一项经机构审查委员会批准的治疗颈部光损伤的研究。两组的治疗方案均包括使用带有衍射透镜的皮秒脉冲紫翠宝石激光对指定区域进行4次治疗，激光通过6mm手持探头发射，能量密度为0.71 j/cm²，重复频率为10Hz，每隔3周（±7天）进行一次治疗，并在第四次治疗后的1个月和3个月使用标准化数码摄影进行随访。
在每次后续就诊时以及最后一次激光治疗后的1个月和3个月，色素沉着、质地和皱纹的整体外观均有统计学显著改善。治疗医生、患者和一名独立评估人员对从基线到最后一次激光治疗后3个月的临床照片进行了评估。所有手部受试者和胸部受试者在所有3个区域均有改善，且具有统计学显著性。两个研究组均未发生不良事件。
这些研究结果表明，所有接受皮秒嫩肤激光治疗面部以外区域的受试者，不仅色素沉着有显著改善，质地和皱纹也有显著改善。所有患者对激光耐受性良好，无不良反应。在皮秒嫩肤技术中，使用带有衍射透镜的6mm固定光斑尺寸手持探头与皮秒脉冲紫翠宝石激光相结合，不仅为色素沉着异常，而且为手部和颈部的质地不均及皱纹提供了一种安全、低能量但有效的治疗方法。《皮肤药物学杂志》2016年；15(11):1398 - 1401。
