一项关于皮秒翠绿宝石激光联合专用透镜阵列治疗中国人群面部光老化的前瞻性半脸研究。

A Prospective Split-Face Study of the Picosecond Alexandrite Laser With Specialized Lens Array for Facial Photoaging in Chinese.

作者信息

Ge Yiping, Guo Lifang, Wu Qiuju, Zhang Mengli, Zeng Rong, Lin Tong

出版信息

J Drugs Dermatol. 2016 Nov 1;15(11):1390-1396.

Abstract

BACKGROUND

A 755nm picosecond alexandrite laser with a diffractive lens array has been reported for the treatment of acne scar and photoaging with clinical ef cacy. In this study, we evaluated the application of the 755nm picosecond alexandrite laser with a diffractive lens array for facial photoaging in Chinese.

MATERIALS AND METHODS

Ten subjects with moderate facial photoaging were enrolled in a prospective, evaluator-blinded, open-label, and split-face trial to assess the ef cacy and safety of the 755nm picosecond alexandrite laser with a diffractive lens array for facial photoaging. Each subject received a series of four treatment sessions on the right side of the face at two-week intervals. The left side of the face served as the control side. Blinded evaluation of baseline, pre-treatment, and two-month follow-up visit was performed by two independent dermatologists on a 5-point global photoaging scale (GPS) and a 6/8-point Asian photographic scale (APS). Adverse events and discomfort associated with the treatment were also assessed.

RESULTS

Signi cant improvement in photoaged tissue was observed on the treated side of the face, with a mean GPS score decrease from 2.67 to 1.44 at the two-month follow-up visit. A greater improvement in wrinkles was observed (2.78 vs 1.89; P less than 0.05) when com- pared to the improvement in pigmentation (2.67 vs 2.11; P less than 0.05). No changes were observed on the control side. Treatment results improved gradually throughout the treatment program and continued to the two-month follow up. In addition, skin tightening was perceived in all subjects, and shallower nasolabial folds were observed in 60% of the subjects on the treated side of face. Moderate pain and transient erythema were observed as the two main discomforts associated with the treatment.

CONCLUSIONS

The 755nm picosecond alexandrite laser with a diffractive lens array is efficacious and safe for rejuvenation of photodamaged facial tissue in Chinese. J Drugs Dermatol. 2016;15(11):1390-1396..

摘要

背景

据报道，一种带有衍射透镜阵列的755nm皮秒翠绿宝石激光可用于治疗痤疮瘢痕和光老化，具有临床疗效。在本研究中，我们评估了带有衍射透镜阵列的755nm皮秒翠绿宝石激光在中国人群面部光老化治疗中的应用。

材料与方法

招募了10名中度面部光老化受试者，进行一项前瞻性、评估者盲法、开放标签的半脸试验，以评估带有衍射透镜阵列的755nm皮秒翠绿宝石激光治疗面部光老化的疗效和安全性。每位受试者在面部右侧每隔两周接受一系列4次治疗。面部左侧作为对照侧。由两名独立的皮肤科医生采用5分制全球光老化量表（GPS）和6/8分制亚洲照片量表（APS）对基线、治疗前和两个月随访进行盲法评估。还评估了与治疗相关的不良事件和不适。

结果

在面部治疗侧观察到光老化组织有显著改善，在两个月随访时，平均GPS评分从2.67降至1.44。与色素沉着改善情况（2.67对2.11；P<0.05）相比，皱纹改善更明显（2.78对1.89；P<0.05）。对照侧未观察到变化。治疗结果在整个治疗过程中逐渐改善，并持续到两个月随访。此外，所有受试者均感觉到皮肤紧致，60%的受试者在面部治疗侧观察到鼻唇沟变浅。观察到中度疼痛和短暂红斑是与治疗相关的两种主要不适。