von Grote Erika C, Palaniswarmy Kiruthi, Meckfessel Matthew H
J Drugs Dermatol. 2016 Dec 1;15(12):1504-1510.
Occupational irritant contact dermatitis (ICD) affecting the hands is a common and difficult-to-manage condition. Occupations that necessitate contact with harsh chemicals, use of alcohol-based disinfectants, and frequent hand washing elevate the risk of ICD. Management strategies that do not adequately prevent accumulated damage and repair skin, can develop into chronic dermatoses which negatively impact work productivity and quality of life. A 2-step skin-care regimen (Excipial Daily Protection Hand Cream (EP) and Excipial Rapid Repair Hand Cream (ER), Galderma Laboratories, L.P.) has been developed as a daily-use management strategy to protect and repair vulnerable hands. The protective barrier cream is formulated with aluminum chlorohydrate and designed for pre-exposure application to enhance the skin's natural protective barrier and minimize excessive moisture while wearing protective gloves. The repair cream, a lipid-rich formulation, is intended for post-exposure application to rehydrate and facilitate the skin's natural healing process. The results of 3 clinical studies highlighted in this review demonstrate how the use of a 2-step skin-care regimen offers a greater protective effect against ICD than the use of barrier cream alone, and also how the formulation of the barrier cream used in these studies helps minimize the occlusion effect caused by gloves and does not interfere with the antibacterial efficacy of an alcohol-based hand sanitizer. This 2-step skin-care regimen is effectively designed to manage and minimize the risk of ICD development in a variety of patients and provides clinicians an additional tool for helping patients manage ICD. J Drugs Dermatol. 2016;15(12):1504-1510.
职业性刺激性接触性皮炎（ICD）累及手部是一种常见且难以处理的病症。需要接触刺激性化学物质、使用酒精类消毒剂以及频繁洗手的职业会增加患ICD的风险。若管理策略不能充分预防累积损伤和修复皮肤，可能会发展为慢性皮肤病，对工作效率和生活质量产生负面影响。已研发出一种两步护肤方案（Excipial每日防护护手霜（EP）和Excipial快速修复护手霜（ER），高德美实验室有限公司）作为日常管理策略，用于保护和修复易受损的手部。防护屏障霜含有水合氯化铝，专为暴露前使用而设计，可增强皮肤的天然保护屏障，并在佩戴防护手套时减少过多水分。修复霜富含脂质，用于暴露后使用，可补充水分并促进皮肤的自然愈合过程。本综述重点介绍的3项临床研究结果表明，与单独使用屏障霜相比，两步护肤方案对ICD具有更强的保护作用，且这些研究中使用的屏障霜配方有助于将手套引起的封闭效应降至最低，同时不干扰酒精类洗手液的抗菌效果。这种两步护肤方案经过有效设计，可管理并降低各类患者发生ICD的风险，为临床医生提供了一种帮助患者管理ICD的额外工具。《药物皮肤病学杂志》。2016年；15（12）：1504 - 1510。
