Dunn P, Shih L Y, Liaw S J, Kuo T T
Taiwan Yi Xue Hui Za Zhi. 1989 Jul;88(7):673-7.
From July 1978 to June 1987, non-Hodgkin's lymphoma was diagnosed in 667 patients at Chang Gung Memorial Hospital. Forty-eight (7%) patients presented primarily with involvement of Waldeyer's ring; their provisional clinical stage was I or II. The tonsils represented the most frequent site of involvement within Waldeyer's ring. A work-up showed 33.3% of patients with stage I, 50% with stage II, 8.3% with stage III and 8.3% with stage IV. All the patients had diffuse lymphomas. Diffuse large cell (46%) and immunoblastic lymphomas (23%) were the most common histologic subtypes. Eight patients received radiotherapy alone, 39 patients were treated with combination chemotherapy with or without local radiation and one patient was lost to follow-up. Eleven of 16 stage I (69%) and 18 of 23 stage II (78%) patients achieved a complete remission. The median survival for stage I patients was over 54 months and the median survival of stage II was 72 months. There was no significant difference between the stage I and II patients with lymphoma of Waldeyer's ring with respect to the complete remission rate and survival. Stage I patients had a relapse-free survival rate of 55% at 4 years, similar to that (49%) of stage II patients at 8 years. We recommend that chemotherapy be used as primary therapy for those patients with localized aggressive lymphoma of Waldeyer's ring.
1978年7月至1987年6月，长庚纪念医院共诊断出667例非霍奇金淋巴瘤患者。48例（7%）患者主要表现为韦氏环受累；其初步临床分期为I期或II期。扁桃体是韦氏环内最常受累的部位。检查显示，I期患者占33.3%，II期患者占50%，III期患者占8.3%，IV期患者占8.3%。所有患者均为弥漫性淋巴瘤。弥漫性大细胞淋巴瘤（46%）和免疫母细胞淋巴瘤（23%）是最常见的组织学亚型。8例患者仅接受放疗，39例患者接受了联合化疗（有无局部放疗），1例患者失访。16例I期患者中有11例（69%）、23例II期患者中有18例（78%）实现完全缓解。I期患者的中位生存期超过54个月，II期患者的中位生存期为72个月。韦氏环淋巴瘤I期和II期患者在完全缓解率和生存率方面无显著差异。I期患者4年无复发生存率为55%，与II期患者8年的无复发生存率（49%）相似。我们建议，对于局限性侵袭性韦氏环淋巴瘤患者，应以化疗作为主要治疗方法。
