Tseng Ai-Sun
School of Life Sciences, University of Nevada, Las Vegas, 4505 South Maryland Parkway, Box 454004, Las Vegas, Nevada, 89154.
Genesis. 2017 Jan;55(1-2). doi: 10.1002/dvg.23003.
Studies of Xenopus eye development have contributed considerably to the understanding of vertebrate neurogenesis, including eye field specification, cell fate determination and identification of genes critical for eye formation. This knowledge has served as a solid foundation for cellular and molecular examinations of the robust regenerative capacity of the Xenopus eye. The retina, lens, and the optic nerve are capable of regeneration after injury in both larval and adult stages. Here, we discuss the current models for studying eye regeneration in Xenopus and their potential applications for providing insights into human eye diseases. As Xenopus has many of the same tools that are available for other regeneration models, we thus highlight the distinct strengths and versatility of this organism that make it especially suited for extrapolating and testing strategies aimed at promoting regeneration and repair in eye tissues. Furthermore, we outline a promising future for the use of new techniques and approaches to address outstanding questions in understanding eye regeneration.
非洲爪蟾眼睛发育的研究极大地促进了对脊椎动物神经发生的理解，包括眼场特化、细胞命运决定以及对眼睛形成至关重要的基因的鉴定。这些知识为对非洲爪蟾眼睛强大再生能力进行细胞和分子研究奠定了坚实基础。视网膜、晶状体和视神经在幼体和成体阶段受伤后都能够再生。在此，我们讨论目前用于研究非洲爪蟾眼睛再生的模型及其在为深入了解人类眼部疾病提供见解方面的潜在应用。由于非洲爪蟾拥有许多与其他再生模型相同的工具，因此我们强调了这种生物体的独特优势和多功能性，使其特别适合推断和测试旨在促进眼组织再生和修复的策略。此外，我们概述了利用新技术和方法解决理解眼睛再生方面悬而未决问题的光明前景。
