磷脂酰肌醇-3激酶抑制剂Perifosine在利什曼原虫中的作用机制
Perifosine Mechanisms of Action in Leishmania Species.
作者信息
López-Arencibia Atteneri, Martín-Navarro Carmen, Sifaoui Ines, Reyes-Batlle María, Wagner Carolina, Lorenzo-Morales Jacob, Maciver Sutherland K, Piñero José E
机构信息
Centre for Integrative Physiology, Biomedical Sciences, Edinburgh Medical School, University of Edinburgh, Edinburgh, United Kingdom
University Institute of Tropical Diseases and Public Health of the Canary Islands, University of La Laguna, Canary Islands, Spain.
出版信息
Antimicrob Agents Chemother. 2017 Mar 24;61(4). doi: 10.1128/AAC.02127-16. Print 2017 Apr.
Abstract
Here the mechanism by which perifosine induced cell death in and is described. The drug reduced mitochondrial membrane potential and decreased cellular ATP levels while increasing phosphatidylserine externalization. Perifosine did not increase membrane permeabilization. We also found that the drug inhibited the phosphorylation of Akt in the parasites. These results highlight the potential use of perifosine as an alternative to miltefosine against .
摘要
本文描述了哌立福新诱导[具体细胞名称1]和[具体细胞名称2]细胞死亡的机制。该药物降低了线粒体膜电位，降低了细胞ATP水平，同时增加了磷脂酰丝氨酸外翻。哌立福新并未增加膜通透性。我们还发现该药物抑制了寄生虫中Akt的磷酸化。这些结果突出了哌立福新作为米替福新治疗[具体疾病名称]替代品的潜在用途。
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