偏头痛时血小板中蛋氨酸脑啡肽而非5-羟色胺的释放。这是偏头痛患者特有的血小板反应吗？

Release of platelet Met-enkephalin, but not serotonin, in migraine. A platelet response unique to migraine patients?

作者信息

Ferrari M D, Odink J, Frölich M, Tapparelli C, Portielje J E

机构信息

Department of Neurology, University Hospital, Leiden, The Netherlands.

出版信息

J Neurol Sci. 1989 Oct;93(1):51-60. doi: 10.1016/0022-510x(89)90160-3.

DOI:10.1016/0022-510x(89)90160-3

PMID:2809630

Abstract

Plasma-induced release of platelet-serotonin and Met-enkephalin was studied by incubating platelets from migraineurs, tension headache patients and healthy volunteers with water, plasma collected during migraine attacks and with plasma collected during attack-free periods. Migraine-attack plasma, but not migraine attack-free plasma, released Met-enkephalin from platelets of migraineurs. Platelets of healthy controls or tension headache sufferers did not release their Met-enkephalin in response to either incubation medium. In contrast to Met-enkephalin, serotonin was not released from platelets in relevant quantities by migraine-attack plasma.

摘要

通过将偏头痛患者、紧张性头痛患者和健康志愿者的血小板分别与水、偏头痛发作期间采集的血浆以及发作间期采集的血浆一起孵育，研究了血浆诱导的血小板 - 血清素和甲硫氨酸脑啡肽的释放情况。偏头痛发作期血浆能从偏头痛患者的血小板中释放甲硫氨酸脑啡肽，而发作间期血浆则不能。健康对照者或紧张性头痛患者的血小板不会因任何一种孵育介质而释放其甲硫氨酸脑啡肽。与甲硫氨酸脑啡肽不同，偏头痛发作期血浆不会使血小板释放出大量血清素。