Kojima H, Furuta Y, Fujita M, Fujioka Y, Nagashima K
Department of Pathology, Hokkaido University School of Medicine, Sapporo, Japan.
J Neurol Sci. 1989 Oct;93(1):85-92. doi: 10.1016/0022-510x(89)90163-9.
Onuf's nucleus, located in the anterior horn of the sacral spinal cord, has been shown to innervate the striated muscles of the urethral and anal sphincters and is known to be well preserved in patients who have motoneuron disease. To answer the question whether the nucleus is also safe from motoneurotrophic virus infections, we examined the spinal cords of 3 individuals who had suffered severe poliomyelitis. In 2 of these which were acutely fatal cases, all motoneurons were damaged by neuronophagia, but Onuf's nucleus escaped the inflammatory degeneration. In a chronic case, neuronal loss in the anterior horn with replacement by gliosis was prominent below the thoracic cord down to the sacral cord, but Onuf's nucleus was well preserved. Thus, Onuf's nucleus appears to differ from other motoneurons with regard to susceptibility to poliovirus infection.
位于骶髓前角的奥努夫核，已被证明支配尿道和肛门括约肌的横纹肌，并且已知在患有运动神经元疾病的患者中保存完好。为了回答该核是否也能免受运动神经元营养病毒感染这一问题，我们检查了3例患有严重脊髓灰质炎患者的脊髓。在其中2例急性致命病例中，所有运动神经元均因噬神经细胞现象而受损，但奥努夫核未发生炎性退变。在1例慢性病例中，胸髓以下直至骶髓的前角神经元丢失并被胶质增生替代的情况很明显，但奥努夫核保存完好。因此，奥努夫核在对脊髓灰质炎病毒感染的易感性方面似乎与其他运动神经元不同。
