Baheti Akshay D, Jagannathan Jyothi P, O'Neill Ailbhe, Tirumani Harika, Tirumani Sree Harsha
Department of Radiology, Tata Memorial Centre, Mumbai 400012, India.
Department of Radiology, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Imaging, Dana-Farber Cancer Institute, Boston, MA 02215, USA.
Korean J Radiol. 2017 Jan-Feb;18(1):94-106. doi: 10.3348/kjr.2017.18.1.94. Epub 2017 Jan 5.
Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013 World Health Organization (WHO) has revised their classification based on new immunohistochemical and cytogenetic data. In this article, we will provide a brief overview of the revised WHO classification of soft tissue tumors, discuss in detail the radiology and management of the two most common adult non-GIST STS, namely liposarcoma and leiomyosarcoma, and review some of the emerging histology-driven targeted therapies in non-GIST STS, focusing on the role of the radiologist.
非胃肠道间质瘤（GIST）的软组织肉瘤（STS）是一组异质性肿瘤，随着对其生物学行为的深入了解，其分类和管理方法也在不断发展。2013年世界卫生组织（WHO）根据新的免疫组织化学和细胞遗传学数据对其分类进行了修订。在本文中，我们将简要概述WHO软组织肿瘤分类的修订情况，详细讨论两种最常见的成人非GIST STS，即脂肪肉瘤和平滑肌肉瘤的放射学及管理方法，并回顾一些新兴的组织学驱动的非GIST STS靶向治疗方法，重点关注放射科医生的作用。
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