Shah P M, Gänger-Farshid G, Mulert R, Stille W
Zentrum der Inneren Medizin, J.W. Goethe-Universität, Frankfurt am Main, FRG.
J Chemother. 1989 May;1 Suppl 2:45-8.
The in vitro bactericidal activity of tigemonam, alone and in combination with gentamicin, was evaluated against various strains of Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Salmonella enteritidis, Enterobacter cloacae, Proteus mirabilis, and Proteus vulgaris. Minimum inhibitory and bactericidal concentrations were determined on three consecutive days with an inoculum of 10(5) colony-forming units (CFU)/mL or a culture in the logarithmic growth phase. The results found tigemonam to be rapidly bactericidal against most Enterobacteriaceae isolated. In addition, the killing curves indicated a synergism between tigemonam and subinhibitory concentrations of gentamicin.
评价了替莫南单独及与庆大霉素联合对多种大肠杆菌、肺炎克雷伯菌、产酸克雷伯菌、肠炎沙门氏菌、阴沟肠杆菌、奇异变形杆菌和普通变形杆菌菌株的体外杀菌活性。连续三天测定最低抑菌浓度和杀菌浓度，接种量为10(5) 菌落形成单位（CFU）/mL或处于对数生长期的培养物。结果发现替莫南对大多数分离出的肠杆菌科细菌具有快速杀菌作用。此外，杀菌曲线表明替莫南与亚抑菌浓度的庆大霉素之间存在协同作用。
