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A Systematic Review of Systemic Cobaltism After Wear or Corrosion of Chrome-Cobalt Hip Implants.钴铬髋关节植入物磨损或腐蚀后全身钴中毒的系统评价
J Patient Saf. 2019 Jun;15(2):97-104. doi: 10.1097/PTS.0000000000000220.
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Occupational causes of sarcoidosis.结节病的职业病因。
Curr Opin Allergy Clin Immunol. 2012 Apr;12(2):145-50. doi: 10.1097/ACI.0b013e3283515173.
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Soluble and particulate Co-Cr-Mo alloy implant metals activate the inflammasome danger signaling pathway in human macrophages: a novel mechanism for implant debris reactivity.可溶性和颗粒性钴铬钼合金植入金属激活人类巨噬细胞中的炎性小体危险信号通路:植入物碎片反应性的一种新机制。
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Severe cobalt intoxication due to prosthesis wear in repeated total hip arthroplasty.反复全髋关节置换术中假体磨损导致的严重钴中毒
J Arthroplasty. 2009 Aug;24(5):825.e15-20. doi: 10.1016/j.arth.2008.07.017. Epub 2008 Oct 2.
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Isolated fracture of the ceramic head after third-generation alumina-on-alumina total hip arthroplasty.第三代氧化铝对氧化铝全髋关节置换术后陶瓷头孤立性骨折
J Bone Joint Surg Am. 2008 Feb;90(2):329-36. doi: 10.2106/JBJS.F.01489.
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Sarcoidosis.结节病
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Orthopaedic metals and their potential toxicity in the arthroplasty patient: A review of current knowledge and future strategies.骨科金属及其在关节置换患者中的潜在毒性:当前知识与未来策略综述
J Bone Joint Surg Br. 2007 May;89(5):567-73. doi: 10.1302/0301-620X.89B5.18903.
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Systemic granulomatous reaction to a foreign body after hip replacement.
N Engl J Med. 1996 Jul 11;335(2):133-4. doi: 10.1056/NEJM199607113350214.
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Metal toxicity and the respiratory tract.金属毒性与呼吸道
Eur Respir J. 1990 Feb;3(2):202-19.

肉芽肿性肺病:髋关节置换术后金属沉着病的一种新型并发症。

Granulomatous Lung Disease: A Novel Complication following Metallosis from Hip Arthroplasty.

作者信息

Balbouzis Theodoros, Georgiadis Thomas, Grigoris Peter

机构信息

Department of Orthopedics, Iaso General Hospital, Athens, Greece.

Laboratory of Pathology, Hygeia General Hospital, Athens, Greece.

出版信息

Hip Pelvis. 2016 Dec;28(4):249-253. doi: 10.5371/hp.2016.28.4.249. Epub 2016 Dec 28.

DOI:10.5371/hp.2016.28.4.249
PMID:28097115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5240319/
Abstract

A case of a female patient with local and systemic complications of metallosis, following catastrophic wear of a revised hip arthroplasty, is presented. The patient had a history of a fractured ceramic-on-ceramic implant, exchanged with a metal-on-polyethylene prosthesis. Systemic complications included sarcoidosis-like reactions, presenting as granulomatous lung disease, along with chorioretinitis, erythema nodosum, and cardiomyopathy. High local and circulating cobalt and chromium levels established the diagnosis. The patient underwent extensive debridement and implant revision. One year postoperatively, she had no respiratory symptoms or functional impairment. Local and systemic complications of metallosis after hip arthroplasty should be promptly recognized and treated operatively.

摘要

本文报告了一例女性患者,在翻修髋关节置换术后发生灾难性磨损,出现金属中毒的局部和全身并发症。该患者曾有陶瓷对陶瓷植入物骨折病史,后更换为金属对聚乙烯假体。全身并发症包括类肉瘤样反应,表现为肉芽肿性肺病,同时伴有脉络膜视网膜炎、结节性红斑和心肌病。高局部和循环钴及铬水平确立了诊断。患者接受了广泛的清创和植入物翻修。术后一年,她没有呼吸症状或功能障碍。髋关节置换术后金属中毒的局部和全身并发症应及时识别并进行手术治疗。