Intensive Care Unit and Zhejiang Provincial Key Laboratory of Geriatrics, Zhejiang Hospital, 12 Lingyin Road, Hangzhou 310013, China.
Intensive Care Unit, Zhejiang Provincial People's Hospital, 158 Shangtang Road, Hangzhou 310014, China.
Biomed Res Int. 2016;2016:5478394. doi: 10.1155/2016/5478394. Epub 2016 Dec 21.
Arterial stiffness contributes to heart failure and is decreased by angiotensin receptor blockers (ARBs). This cross-sectional study aimed to assess associations of lung function and ARB with arterial stiffness in patients with chronic heart failure. 354 outpatients (168 males; 186 females; 68.2 ± 7.2 years old) with chronic heart failure were evaluated. Lung function parameters, including forced vital capacity (FVC), forced expiratory volume in 1 s (FEV), and FEV to FVC ratio (FEV/FVC), were assessed. The cardio-ankle vascular index (CAVI) was used to estimate arterial stiffness. Unadjusted correlation analyses revealed a positive association of CAVI with ARB but not ACEI, and a negative correlation with FEV ( = -0.2987, < 0.0001). Multiple stepwise regression analyses showed that ARB and FEV1 ( < 0.0001) were independent predicting factors for CAVI. These findings suggest that reduced pulmonary function is associated with increased CAVI. Pulmonary function protection could be used to improve the prognosis in heart failure, but additional studies are necessary.
动脉僵硬度可导致心力衰竭，并可被血管紧张素受体阻滞剂 (ARB) 降低。本横断面研究旨在评估慢性心力衰竭患者的肺功能和 ARB 与动脉僵硬度的相关性。评估了 354 名慢性心力衰竭门诊患者（男性 168 名，女性 186 名，年龄 68.2 ± 7.2 岁）。评估了肺功能参数，包括用力肺活量 (FVC)、1 秒用力呼气量 (FEV) 和 FEV/FVC 比值。使用心踝血管指数 (CAVI) 来评估动脉僵硬度。未经调整的相关分析显示，CAVI 与 ARB 呈正相关，而与 ACEI 无关，与 FEV 呈负相关 ( = -0.2987， < 0.0001)。逐步多元回归分析显示，ARB 和 FEV1 ( < 0.0001) 是 CAVI 的独立预测因素。这些发现表明，肺功能降低与 CAVI 增加相关。保护肺功能可能有助于改善心力衰竭的预后，但还需要进一步的研究。
