Good J L, Barry E, Fishman P S
Department of Neurology, University of Maryland School of Medicine, Baltimore.
J Neurosurg. 1989 Nov;71(5 Pt 1):765-7. doi: 10.3171/jns.1989.71.5.0765.
Although sleep disturbances following head injury are common, well-documented posttraumatic narcolepsy has rarely been reported. A patient with all four major features of narcolepsy following significant head injury is presented. Tissue typing revealed the presence of the human lymphocyte antigen DR2, which is strongly associated with idiopathic narcolepsy. Interaction between the brain injury and a genetic predisposition appears to be involved in the development of posttraumatic narcolepsy.
尽管头部受伤后睡眠障碍很常见，但有充分记录的创伤后发作性睡病却鲜有报道。本文介绍了一名在严重头部受伤后出现发作性睡病所有四大主要特征的患者。组织分型显示存在人类淋巴细胞抗原DR2，这与特发性发作性睡病密切相关。脑损伤与遗传易感性之间的相互作用似乎参与了创伤后发作性睡病的发生发展。
