A man-made disease: Fetal neonatal alloimmune thrombocytopenia due to incompatibility between oocyte donor and gestational mother.
作者信息
Barg Assaf Arie, Ifrah Aviya Dvir, Strauss Tzipi, Simchen Michal J, Orvieto Raoul, Rosenberg Nurit, Kenet Gili
机构信息
Thrombosis Institute and National Hemophilia Center, Sheba Medical Center, Tel Hashomer and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Department of Neonatology, The Edmond and Lili Safra Children's Hospital, Sheba Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
出版信息
Pediatr Blood Cancer. 2017 Aug;64(8). doi: 10.1002/pbc.26447. Epub 2017 Jan 18.
The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the first report of FNAIT in which the suggested mechanism involves antibodies produced by a gestational mother against the incompatible HPA of the oocyte donor.
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