Thompson Nicola, Adams David J, Ranzani Marco
Experimental Cancer Genetics, The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK.
Pigment Cell Melanoma Res. 2017 Mar;30(2):183-193. doi: 10.1111/pcmr.12573. Epub 2017 Mar 11.
Great progress has been made in the treatment of melanoma through use of targeted therapies and immunotherapy. One approach that has not been fully explored is synthetic lethality, which exploits somatically acquired changes, usually driver mutations, to specifically kill tumour cells. We outline the various approaches that may be applied to identify synthetic lethal interactions and define how these interactions may drive drug discovery efforts.
通过使用靶向疗法和免疫疗法，黑色素瘤的治疗取得了巨大进展。一种尚未得到充分探索的方法是合成致死性，它利用体细胞获得的变化，通常是驱动突变，来特异性杀死肿瘤细胞。我们概述了可用于识别合成致死相互作用的各种方法，并定义了这些相互作用如何推动药物研发工作。
