对父母患有早发性冠状动脉疾病的儿童的血脂谱及动脉粥样硬化的一些危险因素进行评估。
Assessment of lipid profile and some risk factors of atherosclerosis in children whose parents had early onset coronary artery disease.
作者信息
Bornaun Helen, Öner Naci, Nişli Kemal, Öztarhan Kazım, Yavuz Taner, Türkoğlu Ümit, Dindar Aygün, Eker Ömeroglu Rukiye
机构信息
Pediatric Cardiologist in Pediatric Cardiology Clinic, Sultan Süleyman Education and Research Hospital, Istanbul, Turkey.
Pediatric Cardiology Department, Yeni Yüzyıl University, Istanbul,
出版信息
Arch Argent Pediatr. 2017 Feb 1;115(1):50-54. doi: 10.5546/aap.2017.eng.50.
BACKGROUND/AIM: The objective of our study was to analyze the lipid profile and some risk factors of atherosclerosis such as oxidized-low density lipoprotein (ox-LDL), small dense LDL (sd LDL) in the offspring of patients with premature coronary heart disease (CHD).
POPULATION AND METHODS
Children whose parents had early onset CHD were matched with age and sex pairs. Study and controls were analyzed for lipid levels, apolipoproteins (Apo- A,B,E), ox-LDL, sd LDL and lipoprotein (a) [Lp(a)]. The data were evaluated with SPSS using "Student t and Mann-Whitney U" tests.
RESULTS
The study group children (n: 43) had higher LDL, Lp(a) and ox-LDL levels, ratios of TC/HDL, Apo-B/A, LDL/HDL and ox-LDL/HDL (p<0.05) than control group.
CONCLUSION
These findings suggest that dyslipidemia and increased LDL, Lp(a) and ox-LDL levels are common in the offspring of patients with early onset CHD and account largely for their familial predisposition for CHD.
背景/目的：我们研究的目的是分析早发冠心病（CHD）患者后代的血脂谱以及动脉粥样硬化的一些危险因素，如氧化型低密度脂蛋白（ox-LDL）、小而密低密度脂蛋白（sd LDL）。
研究对象与方法
父母患有早发冠心病的儿童按年龄和性别配对。对研究组和对照组进行血脂水平、载脂蛋白（Apo-A、B、E）、ox-LDL、sd LDL和脂蛋白（a）[Lp(a)]分析。使用SPSS软件，通过“Student t检验和Mann-Whitney U检验”对数据进行评估。
结果
研究组儿童（n = 43）的低密度脂蛋白、Lp(a)和ox-LDL水平，总胆固醇/高密度脂蛋白、载脂蛋白B/载脂蛋白A、低密度脂蛋白/高密度脂蛋白和ox-LDL/高密度脂蛋白的比值均高于对照组（p<0.05）。
结论
这些发现表明，血脂异常以及低密度脂蛋白、Lp(a)和ox-LDL水平升高在早发冠心病患者后代中很常见，这在很大程度上解释了他们患冠心病的家族易感性。
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