Jin Yan, Cao Jia-Ning, Wang Chun-Xia, Feng Qiu-Ting, Ye Xin-He, Xu Xin, Yang Cheng-Jian
Department of Cardiology, WuXi Second Hospital, Nanjing Medical University, 68 Zhongshan Road, Wuxi 214002, China.
Biomark Med. 2017 Feb;11(2):133-139. doi: 10.2217/bmm-2016-0240. Epub 2017 Jan 18.
We investigated the predictive value of chitinase-like protein YKL-40 in coronary artery disease (CAD).
Serum YKL-40 levels in 116 CAD patients and 82 healthy controls were analyzed. Severity of CAD was evaluated using Gensini scores. Spearman's correlation was used to evaluate the correlation between Gensini scores and YKL-40 levels. The predictive value of YKL-40 was determined by receivers operating characteristic curve analysis.
Serum YKL-40 levels were significantly elevated in CAD group as compared with control group. A positive correlation was found between the serum YKL-40 level and Gensini score. The optimum cut-off value of YKL-40 concentration was 127.7 ng/ml for distinguishing CAD patients from healthy controls with a 75.9% sensitivity and 57.3% specificity.
A positive correlation exists between YKL-40 levels and CAD, and YKL-40 might be a useful adjunct in the diagnosis of CAD.
我们研究了几丁质酶样蛋白YKL-40在冠状动脉疾病（CAD）中的预测价值。
分析了116例CAD患者和82例健康对照者的血清YKL-40水平。使用Gensini评分评估CAD的严重程度。采用Spearman相关性分析评估Gensini评分与YKL-40水平之间的相关性。通过受试者工作特征曲线分析确定YKL-40的预测价值。
与对照组相比，CAD组血清YKL-40水平显著升高。血清YKL-40水平与Gensini评分呈正相关。YKL-40浓度的最佳截断值为127.7 ng/ml，用于区分CAD患者与健康对照者，灵敏度为75.9%，特异性为57.3%。
YKL-40水平与CAD之间存在正相关，YKL-40可能是CAD诊断中的有用辅助指标。
