Meinig R P, Quick A, Lobmeyer L
Department of Orthopaedics, University of Colorado Health Sciences Center, Denver.
J Orthop Trauma. 1989;3(3):187-91. doi: 10.1097/00005131-198909000-00001.
Venous plasma levels of lidocaine were determined in 8 patients presenting to the emergency department with acute distal radius fractures and who had had anesthesia with fracture hematoma block. The block was performed in an aseptic fashion via a dorsal approach with a dose of 2.2-2.4 mg/kg of lidocaine without epinephrine. Onset of anesthesia was in less than 5 min which reduced pain from manipulation of the fracture to modest levels. Plasma lidocaine levels determined by gas chromatography-mass spectrometry reflected rapid systemic absorption of lidocaine from the fracture hematoma. Maximum systemic concentrations were seen at 20-30 min and ranged from 100 to 1,100 ng/ml, well below the toxic threshold of 5,000 ng/ml.
对8例因急性桡骨远端骨折就诊于急诊科且接受骨折血肿阻滞麻醉的患者测定了利多卡因的静脉血浆水平。该阻滞通过背侧入路以无菌方式进行，利多卡因剂量为2.2 - 2.4mg/kg，不含肾上腺素。麻醉起效时间不到5分钟，这将骨折手法复位时的疼痛减轻至适度水平。通过气相色谱 - 质谱法测定的血浆利多卡因水平反映了利多卡因从骨折血肿中的快速全身吸收。最大全身浓度出现在20 - 30分钟，范围为100至1100ng/ml，远低于5000ng/ml的中毒阈值。
