Quinton D N
Leicester Royal Infirmary.
Injury. 1988 Jul;19(4):239-40. doi: 10.1016/0020-1383(88)90034-4.
Nine patients undergoing manipulation of Colles' fractures with varying doses of local anaesthetic injected into the fracture haematoma, were investigated by monitoring the arterial levels of lignocaine. Although the procedure was considered satisfactory by all patients, potentially toxic concentrations of lignocaine were found in the arterial circulation, reaching a maximum after manipulation of the fracture. A mean peak level of 2625 micrograms/l was found when 10 ml of 2 per cent lignocaine was used and a mean peak level of 846 micrograms/l in patients receiving 10 ml of 1 per cent lignocaine.
对9例科雷氏骨折患者进行骨折血肿内注射不同剂量局部麻醉药的手法复位治疗，并通过监测动脉血中利多卡因水平进行研究。尽管所有患者都认为该操作令人满意，但在动脉循环中发现了潜在的利多卡因中毒浓度，在骨折手法复位后达到最高值。使用10毫升2%利多卡因时，平均峰值水平为2625微克/升，而接受10毫升1%利多卡因的患者平均峰值水平为846微克/升。
