Department of Anesthesia and Intensive Care, University Hospital Marburg, Baldingerstrasse, 35033 Marburg, Germany.
Department of Orthopedic and Trauma Surgery, University Hospital Marburg, Baldingerstrasse, 35033 Marburg, Germany.
Sci Rep. 2017 Jan 18;7:40875. doi: 10.1038/srep40875.
Dantrolene was introduced for treatment of malignant hyperthermia. It also has antiarrhythmic properties and may thus be an alternative to amiodarone for the treatment of ventricular fibrillation (VF). Aim of this study was to compare the return of spontaneous circulation (ROSC) with dantrolene and amiodarone in a pig model of cardiac arrest. VF was induced in anesthetized pigs. After 8 min of untreated VF, chest compressions and ventilation were started and one of the drugs (amiodarone 5 mg kg, dantrolene 2.5 mg kg or saline) was applied. After 4 min of initial CPR, defibrillation was attempted. ROSC rates, hemodynamics and cerebral perfusion measurements were measured. Initial ROSC rates were 7 of 14 animals in the dantrolene group vs. 5 of 14 for amiodarone, and 3 of 10 for saline). ROSC persisted for the 120 min follow-up in 6 animals in the dantrolene group, 4 after amiodarone and 2 in the saline group (n.s.). Hemodynamics were comparable in both dantrolene group amiodarone group after obtaining ROSC. Dantrolene and amiodarone had similar outcomes in our model of prolonged cardiac arrest, However, hemodynamic stability was not significantly improved using dantrolene. Dantrolene might be an alternative drug for resuscitation and should be further investigated.
丹曲林钠被用于治疗恶性高热。它也具有抗心律失常的特性，因此可能是胺碘酮治疗心室颤动（VF）的替代药物。本研究的目的是比较在心脏骤停的猪模型中使用丹曲林钠和胺碘酮对自主循环恢复（ROSC）的影响。在麻醉猪中诱导 VF。在未经治疗的 VF 持续 8 分钟后，开始进行胸外按压和通气，并给予一种药物（胺碘酮 5mg/kg、丹曲林钠 2.5mg/kg 或生理盐水）。在初始 CPR 开始 4 分钟后，尝试除颤。测量 ROSC 率、血液动力学和脑灌注测量值。丹曲林钠组有 7 只动物在初始 CPR 后出现 ROSC，胺碘酮组有 5 只，生理盐水组有 3 只。在丹曲林钠组中，有 6 只动物在 120 分钟的随访中持续出现 ROSC，胺碘酮组有 4 只，生理盐水组有 2 只（无统计学差异）。在获得 ROSC 后，丹曲林钠组和胺碘酮组的血液动力学相似。在我们的长时间心脏骤停模型中，丹曲林钠和胺碘酮的结果相似，但是，丹曲林钠并不能显著改善血液动力学稳定性。丹曲林钠可能是一种复苏的替代药物，应该进一步研究。
