Kato Y
Nihon Jibiinkoka Gakkai Kaiho. 1989 Jun;92(6):886-92. doi: 10.3950/jibiinkoka.92.886.
Although the etiology of Sjögren's syndrome (SJS) remains unknown, Sjögren's syndrome can be diagnosed by means of clinical features and sialographic and histopathological examinations. In this study of 35 patients with primary SJS and 21 with secondary SJS, two parameters, (the findings of sialography of parotid gland and the histopathology of labial minor salivary gland), were evaluated. Then it was concluded that grade of lesion in sialography was parallel to infiltrative grade of round cells around labial salivary gland in primary SJS but not in secondary SJS. Using monoclonal antibodies to cell surface antigens, lymphocyte subsets in 16 patients with primary SJS and 4 patients with secondary SJS were studied. A predominance of T cells was found and there was no definitive characterization of lymphocyte subset infiltration, between CD4 positive cell and CD8 positive cell. This result was different from the previous reports, and needs further studies.
尽管干燥综合征（SJS）的病因尚不清楚，但可通过临床特征以及唾液造影和组织病理学检查来诊断干燥综合征。在这项针对35例原发性干燥综合征患者和21例继发性干燥综合征患者的研究中，对两个参数（腮腺唾液造影结果和唇小唾液腺组织病理学）进行了评估。结果得出，在原发性干燥综合征中，唾液造影的病变分级与唇唾液腺周围圆形细胞的浸润分级平行，但在继发性干燥综合征中并非如此。使用针对细胞表面抗原的单克隆抗体，对16例原发性干燥综合征患者和4例继发性干燥综合征患者的淋巴细胞亚群进行了研究。发现T细胞占优势，并且在CD4阳性细胞和CD8阳性细胞之间，淋巴细胞亚群浸润没有明确特征。这一结果与先前的报道不同，需要进一步研究。
