Nguyen Nhan Trung, Nguyen Mai Thanh Thi, Nguyen Hai Xuan, Dang Phu Hoang, Dibwe Dya Fita, Esumi Hiroyasu, Awale Suresh
Faculty of Chemistry, University of Science, Vietnam National University, Ho Chi Minh City , 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Vietnam.
Division of Natural Drug Discovery, Institute of Natural Medicine, University of Toyama , 2630 Sugitani, Toyama 930-0194, Japan.
J Nat Prod. 2017 Jan 27;80(1):141-148. doi: 10.1021/acs.jnatprod.6b00784. Epub 2017 Jan 18.
Human pancreatic cancer cell lines have a remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions represents a novel antiausterity strategy in anticancer drug discovery. In this investigation, a methanol extract of the rhizomes of Boesenbergia pandurata showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions, with a PC value of 6.6 μg/mL. Phytochemical investigation of this extract led to the isolation of 15 compounds, including eight new cyclohexene chalcones (1-8). The structures of the new compounds were elucidated by NMR spectroscopic data analysis. Among the isolated compounds obtained, isopanduratin A1 (14) and nicolaioidesin C (15) exhibited potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrition-deprived conditions, with PC values of 1.0 and 0.84 μM, respectively.
人胰腺癌细胞系对营养饥饿具有显著的耐受性，这使它们能够在肿瘤微环境中存活。寻找在低营养条件下优先抑制癌细胞存活的药物，是抗癌药物研发中的一种新型抗营养缺乏策略。在本研究中，竹叶莪术根茎的甲醇提取物在营养缺乏条件下对PANC-1人胰腺癌细胞显示出强效的优先细胞毒性，PC值为6.6 μg/mL。对该提取物进行植物化学研究，分离出15种化合物，包括8种新的环己烯查耳酮（1-8）。通过核磁共振光谱数据分析阐明了新化合物的结构。在所分离得到的化合物中，异莪术呋喃二烯A1（14）和尼可莱素C（15）在营养缺乏条件下对PANC-1人胰腺癌细胞显示出强效的优先细胞毒性，PC值分别为1.0和0.84 μM。
