蓬萊葛素 Q-Y，蓬萊葛二聚體代謝物及其對人胰腺癌细胞系 PANC-1 的抗營養缺乏活性。
Panduratins Q-Y, dimeric metabolites from Boesenbergia rotunda and their antiausterity activities against the PANC-1 human pancreatic cancer cell line.
机构信息
Faculty of Chemistry, University of Science, 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Viet Nam; Cancer Research Laboratory, University of Science, 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Viet Nam; Vietnam National University, Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Viet Nam.
Faculty of Chemistry, University of Science, 227 Nguyen Van Cu Street, District 5, Ho Chi Minh City, Viet Nam; Vietnam National University, Quarter 6, Linh Trung Ward, Thu Duc District, Ho Chi Minh City, Viet Nam.
出版信息
Phytochemistry. 2021 Mar;183:112646. doi: 10.1016/j.phytochem.2020.112646. Epub 2021 Jan 6.
A methanolic extract of the rhizomes of Boesenbergia rotunda showed potent preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient deficiency conditions with a PC value of 6.6 μg/mL. Bioactivity-guided phytochemical investigation of the rhizomes of B. rotunda led to the isolation of nine undescribed dimeric metabolites, panduratins Q-Y. Their structures were elucidated based on NMR, MS, and ECD spectroscopic data interpretation. Panduratins Q-S and U-W exhibited potent cytotoxicity towards PANC-1 cell line with the PC values ranging from 0.8 to 6.3 μM. Panduratin W, which possessed a cyclohexenylchalcone-linked flavanone skeleton, showed the most cytotoxicity with a PC value of 0.8 μM under nutrient-deprived medium.
Boesenbergia rotunda 根茎的甲醇提取物在营养缺乏条件下对 PANC-1 人胰腺癌细胞表现出很强的选择性细胞毒性，PC 值为 6.6μg/mL。对 B. rotunda 根茎的生物活性导向植物化学研究导致分离出九个未描述的二聚代谢物， panduratins Q-Y。基于 NMR、MS 和 ECD 光谱数据解释，确定了它们的结构。Panduratins Q-S 和 U-W 对 PANC-1 细胞系表现出强烈的细胞毒性，PC 值范围为 0.8 到 6.3μM。Panduratin W 具有环己烯基查尔酮连接的黄烷酮骨架，在营养缺乏的培养基中表现出最强的细胞毒性，PC 值为 0.8μM。
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