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食管贲门失弛缓症的多学科治疗方法:单中心经验

Multidisciplinary Approach to Esophageal Achalasia: A Single Center Experience.

作者信息

Schlottmann Francisco, Andolfi Ciro, Kavitt Robert T, Konda Vani J A, Patti Marco G

机构信息

1 Department of Surgery, Center for Esophageal Diseases and Swallowing, University of North Carolina , Chapel Hill, North Carolina.

2 Department of Surgery, University of Chicago , Chicago, Illinois.

出版信息

J Laparoendosc Adv Surg Tech A. 2017 Apr;27(4):358-362. doi: 10.1089/lap.2016.0594. Epub 2017 Jan 18.

Abstract

BACKGROUND

The treatment of achalasia is palliative. Pneumatic dilatation (PD) or laparoscopic Heller myotomy (LHM) just eliminates the outflow obstruction allowing easier emptying of the esophagus. The aim of this study was to evaluate the results of a multidisciplinary approach to esophageal achalasia.

MATERIALS AND METHODS

A consecutive series of patients with achalasia treated by a multidisciplinary esophageal team consisting of radiologists, gastroenterologists, and surgeons in a quaternary care center between May 2008 and April 2015 were analyzed.

RESULTS

A total of 147 patients with achalasia underwent LHM and partial fundoplication. Sixty-two patients (42%) had been treated preoperatively with PD and/or botulinum toxin (BT). The preoperative Eckardt score (ES) was 6.4 ± 2. At a median follow-up of 22 months, 128 patients (87%) did well and required no further treatment (ES 0.1). The remaining 19 patients (13%) had recurrence of symptoms and required further treatment: 12 were treated with PD and improved (ES 0.7); 4 were treated with PD and BT and improved (ES 1.3); 3 failed PD. These 3 patients had been treated with multiple sessions of PD and BT before the myotomy. Overall, 144 patients (98%) did well with laparoscopic (87%) or laparoscopic and endoscopic treatment (11%).

CONCLUSIONS

The results of this study show that (a) LHM is an effective treatment modality, (b) PD improved symptoms in the majority of patients with recurrent dysphagia after myotomy and (c) multiple preoperative endoscopic treatments seem to affect outcomes of LHM. Patients with achalasia should be treated in a quaternary care center by a multidisciplinary team.

摘要

背景

贲门失弛缓症的治疗是姑息性的。气囊扩张术(PD)或腹腔镜下Heller肌切开术(LHM)只是消除了流出道梗阻,使食管更容易排空。本研究的目的是评估多学科方法治疗食管贲门失弛缓症的结果。

材料与方法

分析了2008年5月至2015年4月期间在一家四级医疗中心由放射科医生、胃肠病学家和外科医生组成的多学科食管团队治疗的一系列连续性贲门失弛缓症患者。

结果

共有147例贲门失弛缓症患者接受了LHM和部分胃底折叠术。62例患者(42%)术前接受过PD和/或肉毒杆菌毒素(BT)治疗。术前埃卡德特评分(ES)为6.4±2。中位随访22个月时,128例患者(87%)情况良好,无需进一步治疗(ES为0.1)。其余19例患者(13%)症状复发,需要进一步治疗:12例接受PD治疗后症状改善(ES为0.7);4例接受PD和BT治疗后改善(ES为1.3);3例PD治疗失败。这3例患者在肌切开术前接受过多次PD和BT治疗。总体而言,144例患者(98%)通过腹腔镜治疗(87%)或腹腔镜及内镜联合治疗(11%)情况良好。

结论

本研究结果表明,(a)LHM是一种有效的治疗方式,(b)PD改善了大多数肌切开术后复发性吞咽困难患者的症状,(c)术前多次内镜治疗似乎会影响LHM的治疗效果。贲门失弛缓症患者应由多学科团队在四级医疗中心进行治疗。

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