Tsuji K
J Parenter Sci Technol. 1989 Sep-Oct;43(5):240-5.
This article describes a knowledge-based or expert system computer program that can assist in troubleshooting the gel-clot Limulus Amebocyte Lysate (LAL) method for the assay of endotoxin in parenteral products and in-process materials. The program may also be used to train new personnel and/or to assist in the development of an LAL method for a new product or material. The program includes LAL assay information for 31 parenteral products and materials. The program uses rules-of-thumb and intuition to diagnose 155 possible LAL assay problems and logically reduce them to 37 recommended problem solving processes. The program also provides references to support its recommendation.
本文介绍了一种基于知识的或专家系统的计算机程序，该程序可协助解决凝胶凝块鲎试剂（LAL）法在注射用产品和生产过程中的材料内毒素检测问题。该程序还可用于培训新员工和/或协助开发新产品或材料的LAL检测方法。该程序包含31种注射用产品和材料的LAL检测信息。该程序运用经验法则和直觉来诊断155种可能的LAL检测问题，并通过逻辑推理将其简化为37个推荐的问题解决流程。该程序还提供参考文献以支持其建议。
