Elkilani Osama A, Soliman Mohamed A
Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt.
Int J Gynaecol Obstet. 2017 Mar;136(3):280-284. doi: 10.1002/ijgo.12068. Epub 2016 Dec 20.
To assess the relationship between stromal cell-derived factor 1 (SDF-1) and mature endothelial cells in patients with heavy menstrual bleeding (HMB).
In a prospective observational study, women with idiopathic HMB and control individuals attending Menoufia University Hospital, Egypt, between August 2015 and January 2016 were enrolled. The inclusion criteria were a regular menstrual cycle, a normal coagulation study, and no anomalous ultrasonographic or hysteroscopic findings. Blood samples were collected during different phases of the menstrual cycle (day 5, ovulation, day 24) for measurement of the SDF-1 plasma level (by enzyme-linked immunosorbent assay) and for quantification of mature endothelial cells (by flow cytometry).
Overall, 20 women with HMB and 10 control individuals were enrolled. The SDF-1 level was significantly lower in the HMB group than in the control group during all phases of the menstrual cycle (P≤0.05 for all). The percentage of mature endothelial cells was significantly higher in the HMB group than among controls (P<0.001 for all). The SDF-1 level and the percentage of endothelial cells were negatively correlated throughout the cycle (P<0.001 for all).
Some mediators of angiogenesis, such as SDF-1 and endothelial cells, are disturbed in women with idiopathic HMB.
评估重度月经出血（HMB）患者基质细胞衍生因子1（SDF - 1）与成熟内皮细胞之间的关系。
在一项前瞻性观察研究中，纳入了2015年8月至2016年1月期间在埃及曼努菲亚大学医院就诊的特发性HMB女性患者和对照个体。纳入标准为月经周期规律、凝血检查正常、超声或宫腔镜检查无异常发现。在月经周期的不同阶段（第5天、排卵期、第24天）采集血样，用于测量SDF - 1血浆水平（采用酶联免疫吸附测定法）和定量成熟内皮细胞（采用流式细胞术）。
总体而言，纳入了20例HMB女性患者和10例对照个体。在月经周期的所有阶段，HMB组的SDF - 1水平均显著低于对照组（所有P≤0.05）。HMB组成熟内皮细胞的百分比显著高于对照组（所有P<0.001）。在整个周期中，SDF - 1水平与内皮细胞百分比呈负相关（所有P<0.001）。
在特发性HMB女性中，一些血管生成介质，如SDF - 1和内皮细胞，受到干扰。
