Ding W, Zhao Y F, Lu H W, Liang S, Cheng K B, Xu J F
Department of Respiratory and Critical Care Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China.
Zhonghua Jie He He Hu Xi Za Zhi. 2017 Jan 12;40(1):24-28. doi: 10.3760/cma.j.issn.1001-0939.2017.01.006.
To explore the clinical characteristics of bronchiectasis(BR)coexisting in patients with rheumatoid arthritis (RA). One hundred and forty-eight bronchiectasis patients were retrospectively analyzed. These cases were all diagnosed in the Respiratory Department of Shanghai Pulmonary Hospital and Shanghai Gongli Hospital of Pudong New Area during Jan. 2012 to Dec.2015.The patients consisted of 74 males and 74 females, aging from 45 to 79 [mean(65±11)] years. In these patients, coexisting rheumatoid arthritis was found in 34 males and 36 females, aging from 45 to 79[mean(68±12)] years(RA-BR group). Patients with bronchiectasis alone consisted of 40 males and 38 females, aging from 49 to 76 [mean(63±10)] years (BR alone group). Data between the 2 groups of patients were compared, including general clinical features, serum anti-cyclic citrullinated peptide antibodies (anti-CCP), rheumatoid factor (RF), chest high-resolution CT (HRCT), and lung function . FACED scores were used to assess the severity of bronchiectasis. Meanwhile, we analyzed the correlation between anti-CCP and FACED scores in the 2 groups. We observed an increase of serum anti-CCP in RA-BR patients compared with BR alone patients (196±68 versus 64±26, <0.05). In addition, FACED scores in RA-BR patients were higher than those in BR patients (5.2±1.8 versus 3.1±1.4 , < 0.05). Positive correlations between serum anti-CCP levels and FACED scores (=0.678, =0.461, <0.05) in both RA-BR and BR alone groups were observed in this study. The disease severity scores of RA-BR patients were higher than those of patients with BR alone. Levels of serum anti-CCP may act as a predictor for the diagnosis and prognosis of bronchiectasis in patients with RA.
探讨类风湿关节炎（RA）患者合并支气管扩张（BR）的临床特征。对148例支气管扩张患者进行回顾性分析。这些病例均于2012年1月至2015年12月期间在上海肺科医院呼吸内科及上海浦东新区公利医院确诊。患者中男性74例，女性74例，年龄45至79岁[平均（65±11）岁]。其中，34例男性和36例女性合并类风湿关节炎，年龄45至79岁[平均（68±12）岁]（RA-BR组）。单纯支气管扩张患者中男性40例，女性38例，年龄49至76岁[平均（63±10）岁]（单纯BR组）。比较两组患者的一般临床特征、血清抗环瓜氨酸肽抗体（抗CCP）、类风湿因子（RF）、胸部高分辨率CT（HRCT）及肺功能。采用FACED评分评估支气管扩张的严重程度。同时，分析两组中抗CCP与FACED评分的相关性。我们观察到，与单纯BR患者相比，RA-BR患者血清抗CCP升高（196±68 vs 64±26，<0.05）。此外，RA-BR患者的FACED评分高于BR患者（5.2±1.8 vs 3.1±1.4，<0.05）。本研究观察到，RA-BR组和单纯BR组血清抗CCP水平与FACED评分均呈正相关（=0.678，=0.461，<0.05）。RA-BR患者的疾病严重程度评分高于单纯BR患者。血清抗CCP水平可能作为RA患者支气管扩张诊断及预后的预测指标。
