甲状腺原发性鳞状细胞癌对根治性放疗及顺铂同步化疗完全缓解。
Primary squamous cell carcinoma of the thyroid with complete response to radical radiotherapy and concurrent cisplatin-based chemotherapy.
作者信息
Del Rosario Michael, Dasanu Constantin, Tsai Henry, Johnson Robert
机构信息
Eisenhower Medical Center, Rancho Mirage, California, USA.
出版信息
BMJ Case Rep. 2017 Jan 18;2017:bcr2016217143. doi: 10.1136/bcr-2016-217143.
Abstract
Chemoradiotherapy and/or surgery are both potentially radical treatments for squamous cell carcinomas. Squamous cell carcinomas are considered chemosensitive tumours compared to adenocarcinomas or anaplastic thyroid malignancies. A 76-year-old man was found to have T4bN0M0 primary squamous cell carcinoma of the thyroid with encasement of the internal carotid artery. The disease was deemed unresectable. Therefore, he was treated with radical radiotherapy with concurrent cisplatin-based chemotherapy. We discuss herein the aetiology, diagnosis and management of primary squamous cell carcinoma of the thyroid. We demonstrate success of chemoradiotherapy in an unresectable case of a rare and aggressive disease.
摘要
化疗放疗和/或手术都是鳞状细胞癌潜在的根治性治疗方法。与腺癌或间变性甲状腺恶性肿瘤相比，鳞状细胞癌被认为是化疗敏感肿瘤。一名76岁男性被发现患有甲状腺原发性鳞状细胞癌，T4bN0M0，颈内动脉被包裹。该疾病被认为无法切除。因此，他接受了以顺铂为基础的同步化疗的根治性放疗。我们在此讨论甲状腺原发性鳞状细胞癌的病因学、诊断和管理。我们证明了在一例罕见且侵袭性疾病的不可切除病例中化疗放疗的成功。
相似文献
1
Primary squamous cell carcinoma of the thyroid with complete response to radical radiotherapy and concurrent cisplatin-based chemotherapy.
BMJ Case Rep. 2017 Jan 18;2017:bcr2016217143. doi: 10.1136/bcr-2016-217143.
2
Safety and efficacy of concurrent carboplatin plus radiotherapy for locally advanced head and neck cancer patients ineligible for treatment with cisplatin.
Jpn J Clin Oncol. 2015 Dec;45(12):1116-21. doi: 10.1093/jjco/hyv142. Epub 2015 Sep 29.
3
Regional control after concomitant chemoradiotherapy without planned neck dissection in node-positive head and neck squamous cell carcinomas.
Auris Nasus Larynx. 2013 Apr;40(2):211-5. doi: 10.1016/j.anl.2012.07.002. Epub 2012 Aug 4.
4
Phase I trial of dacomitinib, a pan-human epidermal growth factor receptor (HER) inhibitor, with concurrent radiotherapy and cisplatin in patients with locoregionally advanced squamous cell carcinoma of the head and neck (XDC-001).
Invest New Drugs. 2016 Oct;34(5):575-83. doi: 10.1007/s10637-016-0367-2. Epub 2016 Jun 11.
5
Feasibility and tolerance of sequential chemoradiotherapy in squamous cell carcinoma of the head and neck.
Eur J Cancer Care (Engl). 2013 Jan;22(1):32-40. doi: 10.1111/j.1365-2354.2012.01352.x. Epub 2012 Apr 22.
6
Feasibility and efficacy of induction docetaxel, cisplatin, and 5-fluorouracil chemotherapy combined with cisplatin concurrent chemoradiotherapy for nonmetastatic Stage IV head-and-neck squamous cell carcinomas.
Int J Radiat Oncol Biol Phys. 2011 Nov 15;81(4):e237-43. doi: 10.1016/j.ijrobp.2011.03.043. Epub 2011 May 27.
7
IMRT with simultaneous integrated boost and concurrent chemotherapy for locoregionally advanced squamous cell carcinoma of the head and neck.
Int J Radiat Oncol Biol Phys. 2011 Dec 1;81(5):e845-52. doi: 10.1016/j.ijrobp.2010.10.021. Epub 2010 Dec 16.
8
Phase II study of docetaxel, cisplatin, and concurrent radiation followed by platinum-based adjuvant chemotherapy for technically unresectable, locally advanced head and neck squamous cell carcinoma.
Int J Clin Oncol. 2016 Dec;21(6):1030-1037. doi: 10.1007/s10147-016-0997-6. Epub 2016 Jun 15.
9
The efficacy of induction chemotherapy with docetaxel, cisplatin and 5-fluorouracil combined with cisplatin concurrent chemoradiotherapy for locally advanced head and neck squamous cell carcinoma: a matched pair analysis.
Clin Oncol (R Coll Radiol). 2013 Nov;25(11):647-53. doi: 10.1016/j.clon.2013.07.007. Epub 2013 Aug 13.
10
Weekly versus Three-Weekly Cisplatin-based Concurrent Chemoradiotherapy as definitive treatment in Head and Neck Cancer- Where do we stand?
Gulf J Oncolog. 2016 May;1(21):6-11.
引用本文的文献
1
Efficacy of combined immunotherapy and targeted therapy in overcoming barriers to postoperative recurrence in squamous subtype anaplastic thyroid carcinoma with abscess: a case report and literature review.
Front Oncol. 2025 Mar 19;15:1477954. doi: 10.3389/fonc.2025.1477954. eCollection 2025.
2
Progress in diagnosing and treating thyroid squamous cell carcinoma under the 5th edition of WHO classification.
Front Endocrinol (Lausanne). 2024 Jan 18;14:1273472. doi: 10.3389/fendo.2023.1273472. eCollection 2023.
3
Primary and metastatic squamous cell carcinoma of the thyroid gland: Two case reports.
Open Life Sci. 2022 Sep 16;17(1):1148-1154. doi: 10.1515/biol-2022-0475. eCollection 2022.
4
Primary squamous cell carcinoma of the thyroid gland successfully treated with surgical resection and adjuvant chemoradiotherapy.
BMJ Case Rep. 2021 Mar 1;14(3):e241209. doi: 10.1136/bcr-2020-241209.
5
Treatment optimization and prognostic considerations for primary squamous cell carcinoma of the thyroid.
Gland Surg. 2019 Dec;8(6):683-690. doi: 10.21037/gs.2019.11.07.
本文引用的文献
1
Intrathyroidal epithelial thymoma: carcinoma showing thymus-like differentiation mimicking squamous cell carcinoma of the thyroid.
J Nippon Med Sch. 2015;82(1):2-3. doi: 10.1272/jnms.82.2.
2
Primary squamous cell carcinoma of the thyroid gland.
J Surg Case Rep. 2014 Dec 8;2014(12):rju133. doi: 10.1093/jscr/rju133.
3
Primary squamous cell of the thyroid-an abbreviated clinical presentation.
J Otolaryngol Head Neck Surg. 2014 Jun 18;43(1):17. doi: 10.1186/1916-0216-43-17.
4
Palliative radiation in primary squamous cell carcinoma of thyroid: a rare case report.
Indian J Palliat Care. 2013 Sep;19(3):192-4. doi: 10.4103/0973-1075.121541.
5
Primary squamous cell carcinoma of the thyroid with cardiac metastases and right ventricle outflow tract obstruction.
J Clin Oncol. 2012 Sep 10;30(26):e260-3. doi: 10.1200/JCO.2011.39.9808. Epub 2012 May 29.
6
Primary squamous cell carcinoma of thyroid: a case report and review of literature.
Head Neck Oncol. 2012 Mar 27;4:8. doi: 10.1186/1758-3284-4-8.
7
Squamous cell carcinoma of the thyroid gland: primary or secondary disease?
J Laryngol Otol. 2011 Jan;125(1):3-9. doi: 10.1017/S0022215110002070. Epub 2010 Oct 18.
8
Meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 93 randomised trials and 17,346 patients.
Radiother Oncol. 2009 Jul;92(1):4-14. doi: 10.1016/j.radonc.2009.04.014. Epub 2009 May 14.
9
Case-control study of human papillomavirus and oropharyngeal cancer.
N Engl J Med. 2007 May 10;356(19):1944-56. doi: 10.1056/NEJMoa065497.
10
Primary squamous cell carcinoma of the thyroid: report of ten cases.
Thyroid. 2006 Jan;16(1):89-93. doi: 10.1089/thy.2006.16.89.
Zotero 插件