Zhao Xing, Hao Pengyu, Tian Jiangbei, Sun Jirun, Chen Dawei, Cui Zhehui, Xin Libo, Song Yanmin, Zhang Gang
Department of Pathology, Affiliated Hospital of Chengde Medical College, Chengde, Hebei 067000, P.R. China.
Department of General Surgery IV, Baoding First Hospital, Zhonghua Road, Baoding, Hebei 071000, P.R. China.
Open Life Sci. 2022 Sep 16;17(1):1148-1154. doi: 10.1515/biol-2022-0475. eCollection 2022.
This study reports two cases of squamous cell carcinoma of the thyroid (SCCT) presenting as the thyroid goiter, involving one case of primary squamous cell carcinoma originating from the thyroid (PSCCT) and the other case of secondary SCCT of the thyroid. A retrospective analysis of the clinical and pathological findings was done in this study report. In case 1, the thyroid ultrasound showed multi-hypoechoic well-defined nodules, labeled as 3 using Thyroid Imaging Reporting and Data System, measuring 34.1 mm × 28.9 mm × 30.3 mm and 26.5 mm × 22.2 mm × 23.9 mm in the left in the right lobar thyroid, respectively. The patient underwent surgery and was histologically diagnosed with PSCCT. In case 2, the thyroid ultrasound showed a 25.2 mm × 22.2 mm × 18.8 mm hypoechoic nodule in the right lobar thyroid. The patient underwent a frozen biopsy, the results of which increased suspicion of squamous cell carcinoma. A frozen biopsy was followed by an endoscopic evaluation that detected an ulcerative mass measuring 3.0 cm within the mucosa of esophagus. Due to a scarcity of cases, SCCT is a great challenge for the pathologists and the managing team to come up with the best treatment strategy for the patients.
本研究报告了两例表现为甲状腺肿的甲状腺鳞状细胞癌（SCCT）病例，其中一例为起源于甲状腺的原发性鳞状细胞癌（PSCCT），另一例为甲状腺继发性SCCT。本研究报告对临床和病理结果进行了回顾性分析。病例1中，甲状腺超声显示多个边界清晰的低回声结节，根据甲状腺影像报告和数据系统分类为3类，左叶甲状腺结节大小分别为34.1毫米×28.9毫米×30.3毫米，右叶甲状腺结节大小为26.5毫米×22.2毫米×23.9毫米。患者接受了手术，组织学诊断为PSCCT。病例2中，甲状腺超声显示右叶甲状腺有一个25.2毫米×22.2毫米×18.8毫米的低回声结节。患者接受了冰冻活检，结果增加了对鳞状细胞癌的怀疑。冰冻活检后进行了内镜评估，发现食管黏膜内有一个3.0厘米的溃疡性肿块。由于病例稀少，SCCT对病理学家和管理团队来说是一个巨大挑战，难以提出针对患者的最佳治疗策略。
