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支架植入术后高灌注综合征与支架再狭窄的相关性。

Correlation between high perfusion syndrome and stent restenosis after stent implantation.

作者信息

Li Yingyi, Tang Lingtao, Qi Dong, Wang Chunlei, Zhang Suxia, Hu Pengfei, Wang Yun, Zhang Bogang, Zhang Kunxi

机构信息

Department of Neurology, The Third Hospital of Xingtai City, Xingtai, Hebei 054000, P.R. China.

Department of Neurology, People's Hospital of Wei County, Xingtai, Hebei 054000, P.R. China.

出版信息

Exp Ther Med. 2016 Dec;12(6):3675-3679. doi: 10.3892/etm.2016.3813. Epub 2016 Oct 18.

Abstract

The present study was conducted to determine the correlation between high perfusion syndrome and stent restenosis after cerebral vascular stent implantation. A total of 146 patients diagnosed with cerebral vascular stenosis and stent implantation were selected. A total of 55 cases (37.67%) of cerebral hyperperfusion syndrome patients were diagnosed by xenon-enhanced computer tomography (Xe-CT) examination and clinical symptoms within 3 days after surgery and were chosen as the observation group. A total of 91 cases were selected as the control group. After treatment, blood flow of the anterior cerebral artery, middle cerebral artery, posterior cerebral artery, anterior border zone, posterior border zone and the inner border zone of the two groups increased, with values in the observation group increasing more significantly, and the differences were statistically significant (P<0.05). The rate of restenosis and target lesion diameter one month and one year after operation in the observation group were significantly higher than those in the control group (P<0.05). Multivariate logistic regression analysis showed that the mean systolic blood pressure (mSBP), mean diastolic blood pressure (mDBP), stenosis rate of cerebral vascular diameter and high perfusion syndrome were independent risk factors for restenosis (P<0.05). The application of Xe-CT examination is important for early diagnosis of hyperperfusion syndrome. Hyperperfusion syndrome and the occurrence of stent restenosis are closely related. mSBP, mDBP, cerebral blood vessel diameter stenosis rate and high perfusion comprehensive syndrome are the independent risk factors of restenosis.

摘要

本研究旨在确定脑血管支架植入术后高灌注综合征与支架再狭窄之间的相关性。共选取146例诊断为脑血管狭窄并行支架植入术的患者。其中55例(37.67%)在术后3天内通过氙增强计算机断层扫描(Xe-CT)检查及临床症状诊断为脑高灌注综合征患者,作为观察组。选取91例作为对照组。治疗后,两组大脑前动脉、大脑中动脉、大脑后动脉、前交界区、后交界区及内交界区的血流均增加,观察组增加更显著,差异有统计学意义(P<0.05)。观察组术后1个月及1年的再狭窄率及靶病变直径均显著高于对照组(P<0.05)。多因素logistic回归分析显示,平均收缩压(mSBP)、平均舒张压(mDBP)、脑血管直径狭窄率及高灌注综合征是再狭窄的独立危险因素(P<0.05)。Xe-CT检查的应用对高灌注综合征的早期诊断具有重要意义。高灌注综合征与支架再狭窄的发生密切相关。mSBP、mDBP、脑血管直径狭窄率及高灌注综合征是再狭窄的独立危险因素。

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