[运动对尿酸排泄的影响]
[Effect of exercise on urate excretion].
作者信息
Goto H, Ito A, Mikami T
机构信息
Institude of Health and Sports Sciences, University of Tsukuba, Ibaragi, Japan.
出版信息
Nihon Seirigaku Zasshi. 1989;51(7):208-20.
Bidirectional renal urate transport was studied in normal male subjects, aged 21-26 yr. They performed a exhaustive running on treadmill for about 10 mins, after oral intake of each medicine. The used medicines were probenecid inhibited presecretory reabsorption, pyrazinamide inhibited tubular secretion and benzbromarone inhibited postsecretory reabsorption. The results were as follows: 1) Glomerular filtration rate decreased only 3 min after exercise, compared with resting level. 2) Presecretory reabsorption rate did not change substantially after exercise, compared with resting level. 3) Tubular secretion rate markedly decreased at 30 min and 1 hour after exercise, compared with resting level. 4) Postsecretory reabsorption rate changed as well as changes in tubular secretion rates.
在年龄为21 - 26岁的正常男性受试者中研究了双向肾尿酸转运。在口服每种药物后，他们在跑步机上进行了约10分钟的力竭性跑步。所使用的药物中，丙磺舒抑制分泌前重吸收，吡嗪酰胺抑制肾小管分泌，苯溴马隆抑制分泌后重吸收。结果如下：1）与静息水平相比，运动后仅3分钟肾小球滤过率就下降了。2）与静息水平相比，运动后分泌前重吸收率没有实质性变化。3）与静息水平相比，运动后30分钟和1小时肾小管分泌率显著下降。4）分泌后重吸收率与肾小管分泌率的变化一样也发生了改变。
Zotero 插件