Squires Bryan, Daveluy Steven D, Joiner Michael C, Hurst Newton, Bishop Michael, Miller Steven R
Karmanos Cancer Institute, Wayne State University, 4100 John R St., Detroit, MI 48201, USA.
Case Rep Dermatol Med. 2016;2016:7137691. doi: 10.1155/2016/7137691. Epub 2016 Dec 22.
. Acrokeratosis paraneoplastica, or Bazex syndrome, is a paraneoplastic syndrome characterized by cutaneous psoriasiform lesions with associated acral erythema and scale, as well as nail changes, including onycholysis and ungual dystrophy. Its most advanced, severe form involves the trunk, elbows, and knees. It is typically associated with upper aerodigestive tract malignancies in males. Rare cases associated with gynecological cancers have been reported, including uterine adenocarcinoma, as well as ovarian and vulvar squamous cell carcinomas. Cutaneous manifestations often precede cancer diagnosis. In most reported cases, skin changes resolve when the underlying malignancy is adequately treated. . We present the case of a 56-year-old female diagnosed with acrokeratosis paraneoplastica following the discovery of FIGO stage IIB cervical squamous cell carcinoma (SCC). Scaling, hyperpigmentation, xerosis, and fissuring were noted on the patient's hands, feet, legs, arms, and lower back. Pitting was noted on her fingernails. Her cervical cancer was successfully treated with chemoradiotherapy, after which her cutaneous lesions persisted for two months before resolving. . The presentation of acrokeratosis paraneoplastica in this context is atypical. Reports of associations with gynecological cancers, as in our patient's case, are exceedingly rare.
副肿瘤性肢端角化病，即巴泽克斯综合征，是一种副肿瘤综合征，其特征为皮肤银屑病样病变，并伴有肢端红斑和鳞屑，以及指甲改变，包括甲剥离和甲营养不良。其最严重的形式累及躯干、肘部和膝部。在男性中，它通常与上消化道恶性肿瘤相关。有报道称存在与妇科癌症相关的罕见病例，包括子宫腺癌以及卵巢和外阴鳞状细胞癌。皮肤表现通常先于癌症诊断出现。在大多数报道的病例中，当潜在的恶性肿瘤得到充分治疗时，皮肤改变会消退。我们报告一例56岁女性病例，该患者在被诊断为国际妇产科联盟（FIGO）IIB期宫颈鳞状细胞癌（SCC）后，被诊断为副肿瘤性肢端角化病。在患者的手部、足部、腿部、手臂和下背部发现有鳞屑、色素沉着、皮肤干燥和皲裂。其指甲有凹点。她的宫颈癌通过放化疗成功治疗，之后其皮肤病变持续了两个月才消退。在这种情况下出现的副肿瘤性肢端角化病并不典型。如我们患者的病例所示，与妇科癌症相关的报道极为罕见。
