Brodie Martin J
Epilepsy Unit, West Glasgow ACH-Yorkhill, Dalnair Street, Glasgow, G3 8SJ, Scotland, UK.
CNS Drugs. 2017 Feb;31(2):135-147. doi: 10.1007/s40263-016-0406-8.
This paper discusses the issues surrounding the tolerability and safety of the commonly used antiepileptic drugs (AEDs) in adolescents and adults. The content includes dose-related adverse effects, idiosyncratic reactions, behavioural and psychiatric comorbidities, chronic problems, enzyme induction and teratogenesis. Twenty-one AEDs are discussed in chronological order of their introduction into the UK, starting with phenobarbital and ending with brivaracetam. Wherever possible, advice is given on anticipating, recognising and managing these issues and thereby improving the lives of people with epilepsy, most of whom will need to take one or more of these agents for life. Avoidance of side effects will increase the possibility of achieving and maintaining long-term seizure freedom. Alternatively, adverse events from AEDs will substantially reduce quality of life and often result in higher healthcare costs.
本文讨论了常用抗癫痫药物（AEDs）在青少年和成人中的耐受性和安全性相关问题。内容包括剂量相关不良反应、特异反应、行为和精神共病、慢性问题、酶诱导和致畸作用。按照这些药物引入英国的时间顺序，对21种抗癫痫药物进行了讨论，从苯巴比妥开始，到布瓦西坦结束。只要有可能，就会给出关于预测、识别和处理这些问题的建议，从而改善癫痫患者的生活，其中大多数患者将需要终生服用一种或多种此类药物。避免副作用将增加实现和维持长期无癫痫发作的可能性。否则，抗癫痫药物引起的不良事件将大幅降低生活质量，并常常导致更高的医疗费用。
