Kingston R D, Kiff R S, Duthie J S, Walsh S, Spicer A, Jeacock J
J R Coll Surg Edinb. 1989 Aug;34(4):208-11.
Two hundred and twenty-nine patients were entered into a study to compare the effectiveness and safety of two single-shot antibiotic regimes in patients undergoing elective colorectal surgery in two district general hospitals. A single shot of intravenous (IV) latamoxef disodium was as effective as an IV combination of cefuroxime and metronidazole in control of wound infection following elective large bowel surgery when given as a bolus at the time of anaesthetic induction. The incidence of major wound infection was 6% and was evenly distributed in the two treatment groups. Half the major wound infections were associated with faecal fistulae. A single shot of IV antibiotic at the time of anaesthetic induction was safe, simple and an effective prophylaxis against major wound infection. There was a low incidence (1.3%) of serious postoperative bleeding and no serious adverse reactions were noted. The overall mortality was 9%. Death was significantly related to elderly patients, a poor performance status, operative contamination and wound infections.
229名患者参与了一项研究，以比较两种单次使用抗生素方案在两家地区综合医院接受择期结直肠手术患者中的有效性和安全性。在麻醉诱导时静脉推注一剂拉氧头孢钠，在控制择期大肠手术后的伤口感染方面，其效果与头孢呋辛和甲硝唑的静脉联合用药相同。主要伤口感染的发生率为6%，在两个治疗组中分布均匀。一半的主要伤口感染与粪瘘有关。麻醉诱导时静脉注射一剂抗生素安全、简便，是预防主要伤口感染的有效方法。严重术后出血的发生率较低（1.3%），未观察到严重不良反应。总死亡率为9%。死亡与老年患者、身体状况差、手术污染和伤口感染显著相关。
