性别和食物对酮洛芬立体异构体在人体中的生物利用度及R型到S型转化的影响。 - Suppr

Influence of Sex and Food on the Bioavailability and the R-to-S Conversion of Ketoprofen Stereoisomers in Humans.

作者信息

Fagiolino Pietro, Fotaki Nikoletta, Vázquez Marta

机构信息

Department of Pharmaceutical Sciences, Faculty of Chemistry, Universidad de la República, Av. Gral. Flores 2124, P.O. Box 1157, 11800, Montevideo, Uruguay.

Department of Pharmacy and Pharmacology, University of Bath, Bath, UK.

出版信息

Eur J Drug Metab Pharmacokinet. 2017 Feb;42(1):167-169. doi: 10.1007/s13318-016-0396-4.

DOI:10.1007/s13318-016-0396-4

PMID:28101841

Abstract

摘要

相似文献

Influence of Sex and Food on the Bioavailability and the R-to-S Conversion of Ketoprofen Stereoisomers in Humans.性别和食物对酮洛芬立体异构体在人体中的生物利用度及R型到S型转化的影响。

Eur J Drug Metab Pharmacokinet. 2017 Feb;42(1):167-169. doi: 10.1007/s13318-016-0396-4.

Stereoselective Pharmacokinetics of Ketoprofen After Oral Administration of Modified-Release Formulations in Caucasian Healthy Subjects.酮洛芬在白种健康受试者口服缓释制剂后的立体选择性药代动力学

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Stereoselective Conversion of Ketoprofen in Men Versus Women from Two Different Oral Dosage Formulations: Observations and Introspection of the Pharmacokinetic Data.

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Oral bioavailability and pharmacokinetic characteristics of ketoprofen enantiomers after oral and intravenous administration in Asian elephants (Elephas maximus).亚洲象（Elephas maximus）口服和静脉注射后酮洛芬对映体的口服生物利用度和药代动力学特征

Am J Vet Res. 2003 Jan;64(1):109-14. doi: 10.2460/ajvr.2003.64.109.

Stereoselective pharmacokinetics of ketoprofen in llamas following intravenous administration.静脉注射后，酮洛芬在美洲驼体内的立体选择性药代动力学。

J Vet Pharmacol Ther. 2001 Jun;24(3):223-6. doi: 10.1046/j.1365-2885.2001.00321.x.

Pharmacokinetics of ketoprofen in Japanese quail (Coturnix japonica).酮洛芬在日本鹌鹑（日本鹌鹑）体内的药代动力学。

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Bioavailability of S(+)-ketoprofen after oral administration of different mixtures of ketoprofen enantiomers to dogs.

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Evaluation of bioequivalence after oral, intramuscular, and intravenous administration of racemic ketoprofen in pigs.猪口服、肌肉注射和静脉注射消旋酮洛芬后的生物等效性评估。

Am J Vet Res. 2008 Jan;69(1):108-13. doi: 10.2460/ajvr.69.1.108.

本文引用的文献

Stereoselective Conversion of Ketoprofen in Men Versus Women from Two Different Oral Dosage Formulations: Observations and Introspection of the Pharmacokinetic Data.

Eur J Drug Metab Pharmacokinet. 2017 Feb;42(1):165-166. doi: 10.1007/s13318-016-0395-5.

Eur J Drug Metab Pharmacokinet. 2016 Dec;41(6):787-793. doi: 10.1007/s13318-015-0313-2.

Effect of absorption rate on pharmacokinetics of ibuprofen in relation to chiral inversion in humans.吸收速率对布洛芬在人体内手性转化相关药代动力学的影响。

J Pharm Pharmacol. 2007 Nov;59(11):1509-13. doi: 10.1211/jpp.59.11.0007.

Influence of age on the enantiomeric disposition of ibuprofen in healthy volunteers.年龄对健康志愿者体内布洛芬对映体处置的影响。

Br J Clin Pharmacol. 2003 Jun;55(6):579-87. doi: 10.1046/j.1365-2125.2003.01806.x.

Stereoselective pharmacokinetics and inversion of (R)- ketoprofen in healthy volunteers.

J Clin Pharmacol. 1998 Feb;38(2S):3S-10S. doi: 10.1002/j.1552-4604.1998.tb04411.x.

Lack of effect of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen in humans.性别和口服避孕药类固醇对（R）-布洛芬在人体内药代动力学无影响。

Br J Clin Pharmacol. 1995 Aug;40(2):153-6. doi: 10.1111/j.1365-2125.1995.tb05769.x.

Pharmacokinetics of ketoprofen enantiomers after different doses of the racemate.不同剂量消旋酮洛芬给药后酮洛芬对映体的药代动力学

Br J Clin Pharmacol. 1995 Jul;40(1):73-5. doi: 10.1111/j.1365-2125.1995.tb04537.x.

Pharmacokinetics of ibuprofen enantiomers in humans following oral administration of tablets with different absorption rates.口服不同吸收速率片剂后布洛芬对映体在人体内的药代动力学。

Pharm Res. 1988 Jan;5(1):40-3. doi: 10.1023/a:1015811428066.

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Influence of Sex and Food on the Bioavailability and the R-to-S Conversion of Ketoprofen Stereoisomers in Humans.

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