Machaczka Maciej, Hägglund Hans, Staver Emma, Joks Monika, Hassan Moustapha, Wahlin Björn Engelbrekt, Axdorph Nygell Ulla
Department of Medicine at Huddinge, Karolinska Institutet and Hematology Center Karolinska, Karolinska University Hospital, Stockholm, Sweden.
Department of Medical Sciences, Hematology, Uppsala University, Uppsala, Sweden.
J Clin Apher. 2017 Dec;32(6):384-391. doi: 10.1002/jca.21524. Epub 2017 Jan 19.
Mobilized PBSC are the main source for allogeneic HSCT. We aimed to evaluate factors that affect CD34+ cell yield including the donor's age, gender, BSA, processed blood volume and the method of G-CSF dose calculation. Data from 170 healthy donors were analyzed. The concentration of CD34+ cells in the peripheral blood (PB) and the processed volume of blood were significantly correlated to CD34+ cells yield (P < .00005 and P < .001, respectively). The G-CSF dose per m was significantly correlated to the concentration of CD34+ cells in the PB (P = .0003) and in the product (P = .01). Smaller BSA and less processed volume were found among female donors, who were given lesser G-CSF dose per m , and showed lower yield compared to men. However, multivariate analysis of the yield showed that only the concentration of CD34+ cells in the PB and the processed volume remained independent significant.
动员的外周血干细胞是异基因造血干细胞移植的主要来源。我们旨在评估影响CD34+细胞产量的因素，包括供者的年龄、性别、体表面积、处理的血量以及粒细胞集落刺激因子（G-CSF）剂量计算方法。分析了170名健康供者的数据。外周血（PB）中CD34+细胞的浓度和处理的血量与CD34+细胞产量显著相关（分别为P < 0.00005和P < 0.001）。每平方米的G-CSF剂量与PB中CD34+细胞的浓度（P = 0.0003）和产品中CD34+细胞的浓度（P = 0.01）显著相关。女性供者的体表面积较小，处理的血量较少，每平方米给予的G-CSF剂量较少，与男性相比产量较低。然而，对产量的多因素分析表明，只有PB中CD34+细胞的浓度和处理的血量仍然是独立的显著因素。
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