Farin C E, Sawyer H R, Niswender G D
Department of Physiology, Colorado State University, Fort Collins 80523.
J Reprod Fertil Suppl. 1989;37:181-7.
The parenchyma of the corpus luteum of the ewe consists of two distinct steroidogenic cell types: small luteal cells and large luteal cells. Although both cell types produce and secrete progesterone, they differ with respect to morphological and biochemical characteristics. During the oestrous cycle, and continuing into pregnancy, the cellular composition of the corpus luteum is altered. As the oestrous cycle progresses small luteal cells increase in number but not size whereas large luteal cells remain constant in number but increase in size. Changes in the cellular composition of the ovine corpus luteum appear to be regulated by LH. Moreover, small luteal cells obtained from pregnant ewes were larger and lacked responsiveness to LH compared to those from non-pregnant animals. The basis of this loss of responsiveness is not clear as there is no concomitant loss of receptors for LH. The corpus luteum is a dynamic gland which changes in cellular composition and hormonal responsiveness with alterations in the reproductive state of the animal.
小黄体细胞和大黄体细胞。尽管这两种细胞类型都产生并分泌孕酮，但它们在形态和生化特征方面存在差异。在发情周期以及持续到怀孕过程中，黄体的细胞组成会发生改变。随着发情周期的推进，小黄体细胞数量增加但大小不变，而大黄体细胞数量保持恒定但大小增加。绵羊黄体细胞组成的变化似乎受促黄体生成素（LH）调节。此外，与未怀孕母羊的小黄体细胞相比，怀孕母羊的小黄体细胞更大且对LH缺乏反应性。这种反应性丧失的基础尚不清楚，因为促黄体生成素受体并没有随之丧失。黄体是一个动态腺体，其细胞组成和激素反应性会随着动物生殖状态的改变而变化。
