Lee Priscilla W, Severin Mary E, Lovett-Racke Amy E
Department of Microbial Infection and Immunity, Ohio State University, Columbus, OH, USA.
Eur J Immunol. 2017 Mar;47(3):446-453. doi: 10.1002/eji.201646716. Epub 2017 Feb 10.
Transforming growth factor beta (TGF-β) is a pleiotropic cytokine that has been shown to influence the differentiation and function of T cells. The role that TGF-β plays in immune-mediated disease, such as multiple sclerosis (MS), has become a major area of investigation since CD4 T cells appear to be a major mediator of autoimmunity. This review provides an analysis of the literature on the role that TGF-β plays in the generation and regulation of encephalitogenic and regulatory T cells (Treg) in experimental autoimmune encephalomyelitis (EAE), an animal model of MS, as well as in T cells of MS patients. Since TGF-β plays a major role in the development and function of both CD4 effector and Treg, which are defective in MS patients, recent studies have found potential mechanisms to explain the basis for these T-cell defects to establish a foundation for potentially modulating TGF-β signaling to restore normal T-cell function in MS patients.
转化生长因子β（TGF-β）是一种多效性细胞因子，已被证明可影响T细胞的分化和功能。由于CD4 T细胞似乎是自身免疫的主要介质，TGF-β在免疫介导疾病（如多发性硬化症（MS））中所起的作用已成为一个主要研究领域。本文综述分析了有关TGF-β在实验性自身免疫性脑脊髓炎（EAE，一种MS动物模型）中致脑炎性T细胞和调节性T细胞（Treg）的产生及调控中所起作用的文献，以及MS患者T细胞中相关文献。由于TGF-β在MS患者存在缺陷的CD4效应细胞和Treg的发育及功能中起主要作用，最近的研究已发现潜在机制来解释这些T细胞缺陷的基础，从而为潜在调节TGF-β信号传导以恢复MS患者正常T细胞功能奠定基础。
