Takayoshi Kotoe, Uchino Keita, Nakano Masahiro, Ikejiri Koji, Baba Eishi
a Department of Medical Oncology , Clinical Research Institute, National Hospital Organization Kyushu Medical Center , Fukuoka , Japan.
b Department of Hematology and Oncology , Kyushu University Hospital , Fukuoka , Japan.
Nutr Cancer. 2017 Apr;69(3):408-415. doi: 10.1080/01635581.2017.1267774. Epub 2017 Jan 19.
Patients with advanced gastric cancer (AGC) often suffer weight loss, which can be used to predict prognosis. Few reports have assessed the correlation between weight loss during chemotherapy and survival in patients with AGC.
Fifty-three patients with histologically proven AGC, who started systemic chemotherapy from September 2010 to March 2014, were retrospectively examined for body weight, inflammatory status, and survival. Correlation analyses were performed between weight change and survival. Correlations between weight loss and the patient characteristics were analyzed by stepwise multiple regression analyses.
The mean age of the patients was 64.4 years; 64% of the patients were males. Initial chemotherapy included fluoropyrimidine plus cisplatin (62%), fluoropyrimidine alone (26%), and other medications (12%); 72% of the patients exhibited weight loss during the initial therapy. Poorer mean overall survival and mean progression-free survival were observed in patients with weight loss of higher-than-average values than in those with weight loss of lower-than-average values. Serum C-reactive protein levels were significantly correlated with weight loss.
Weight loss during initial chemotherapy for AGC may predict survival. Systemic inflammation is suggested to be associated with weight loss.
晚期胃癌（AGC）患者常出现体重减轻，这可用于预测预后。很少有报告评估AGC患者化疗期间体重减轻与生存之间的相关性。
对2010年9月至2014年3月开始全身化疗的53例经组织学证实的AGC患者进行回顾性研究，分析其体重、炎症状态和生存情况。进行体重变化与生存之间的相关性分析。通过逐步多元回归分析体重减轻与患者特征之间的相关性。
患者的平均年龄为64.4岁；64%为男性。初始化疗包括氟嘧啶加顺铂（62%）、单纯氟嘧啶（26%）和其他药物（12%）；72%的患者在初始治疗期间出现体重减轻。体重减轻高于平均值的患者的平均总生存期和平均无进展生存期比体重减轻低于平均值的患者更差。血清C反应蛋白水平与体重减轻显著相关。
AGC初始化疗期间的体重减轻可能预测生存。提示全身炎症与体重减轻有关。
