炎症性肠病患者中使用粪便微生物群移植治疗复发性艰难梭菌感染
Treatment of recurrent Clostridium difficile infection using fecal microbiota transplantation in patients with inflammatory bowel disease.
作者信息
Newman Krista M, Rank Kevin M, Vaughn Byron P, Khoruts Alexander
机构信息
a Department of Medicine , University of Minnesota , Minneapolis , Minnesota , USA.
b Center for Immunology and BioTechnology Institute , University of Minnesota , Twin Cities Campus, Minneapolis , Minnesota , USA.
出版信息
Gut Microbes. 2017 May 4;8(3):303-309. doi: 10.1080/19490976.2017.1279377. Epub 2017 Jan 19.
Abstract
We recently compared results of fecal microbiota transplantation (FMT) in patients with refractory, recurrent Clostridium difficile infection (rCDI), with and without underlying inflammatory bowel disease (IBD). Here we extend this cohort and analyze outcomes in greater detail by subtype of IBD. We find that FMT is generally effective in breaking the cycle of CDI recurrence, but its effects on overall IBD progression are much less predictable. We discuss several challenges intrinsic to this complex clinical situation and outline the next steps that can address these challenges going forward.
摘要
我们最近比较了粪便微生物群移植（FMT）在患有难治性复发性艰难梭菌感染（rCDI）且伴有或不伴有潜在炎症性肠病（IBD）的患者中的效果。在此，我们扩大了该队列研究，并按IBD亚型更详细地分析了结果。我们发现FMT通常能有效打破CDI复发的循环，但其对IBD整体进展的影响则更难预测。我们讨论了这种复杂临床情况所固有的几个挑战，并概述了未来应对这些挑战的后续步骤。
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2
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Inflamm Bowel Dis. 2016 Oct;22(10):2402-9. doi: 10.1097/MIB.0000000000000908.
3
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