正性转录延伸因子b：探寻释放启动子近端暂停的RNA聚合酶II的途径。
P-TEFb: Finding its ways to release promoter-proximally paused RNA polymerase II.
作者信息
Li You, Liu Min, Chen Lin-Feng, Chen Ruichuan
机构信息
a State Key Laboratory of Cellular Stress Biology , School of Life Sciences, Xiamen University , Xiamen , China.
b Department of Biochemistry , College of Medicine, University of Illinois at Urbana-Champaign , Urbana , IL , USA.
出版信息
Transcription. 2018;9(2):88-94. doi: 10.1080/21541264.2017.1281864. Epub 2018 Jan 12.
Abstract
The release of a paused Pol II depends on the recruitment of P-TEFb. Recent studies showed that both active P-TEFb and inactive P-TEFb (7SK snRNP) can be recruited to the promoter regions of global genes by different mechanisms. Here, we summarize the recent advances on these distinct recruitment mechanisms.
摘要
暂停的RNA聚合酶II（Pol II）的释放取决于正性转录延伸因子b（P-TEFb）的募集。最近的研究表明，活性P-TEFb和非活性P-TEFb（7SK小核核糖核蛋白）均可通过不同机制募集至全基因组的启动子区域。在此，我们总结了这些不同募集机制的最新进展。
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