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先天性胚胎性横纹肌肉瘤;多发病灶。

Congenital embryonal rhabdomyosarcoma; multiple lesions.

作者信息

Esmaeili Heidarali, Azimpouran Mahzad

机构信息

Department of General pathology, Tabriz University of Medical Science, Tabriz, Iran.

出版信息

Int J Surg Case Rep. 2017;31:47-50. doi: 10.1016/j.ijscr.2016.12.013. Epub 2017 Jan 5.

DOI:10.1016/j.ijscr.2016.12.013
PMID:28103501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5241581/
Abstract

INTRODUCTION

Congenital or neonatal rhabdomyosarcoma (RMS) is a rare soft tissue tumor with the most common sites of origin in genitourinary tract, head, and neck regions and extremities are less commonly involved.

PRESENTATION OF CASE

In this paper, a case of embryonal RMS with skin lesions, lymph nodes metastasis, and bone marrow metastasis is reported for a 1-month old female patient.

DISCUSSION

This study presents how within 8-months of chemotherapy, the lesions got subsided and the patient became disease free.

CONCLUSION

Multiple congenital rhabdomyosarcoma of neonate is a rare finding that should be considered as differential diagnosis of lymphoma and neurofibroma.

摘要

引言

先天性或新生儿横纹肌肉瘤(RMS)是一种罕见的软组织肿瘤,最常见的起源部位是泌尿生殖道、头颈部,四肢较少受累。

病例介绍

本文报告了一名1个月大的女性患者,患有伴有皮肤病变、淋巴结转移和骨髓转移的胚胎性RMS。

讨论

本研究展示了在化疗8个月内,病变如何消退且患者实现无病状态。

结论

新生儿多发性先天性横纹肌肉瘤是一种罕见的发现,应作为淋巴瘤和神经纤维瘤的鉴别诊断考虑。

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本文引用的文献

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Diagnosis and treatment of lymph node metastases in pediatric rhabdomyosarcoma in the Netherlands: a retrospective analysis.荷兰小儿横纹肌肉瘤淋巴结转移的诊断与治疗:一项回顾性分析
J Pediatr Surg. 2014 Mar;49(3):416-9. doi: 10.1016/j.jpedsurg.2013.08.002.
2
A rare case of congenital rhabdomyosarcoma with review of the literature.先天性横纹肌肉瘤1例罕见病例并文献复习
Case Rep Otolaryngol. 2013;2013:518952. doi: 10.1155/2013/518952. Epub 2013 Nov 20.
3
High incidence of regional and in-transit lymph node metastasis in patients with alveolar rhabdomyosarcoma.
肺泡横纹肌肉瘤患者区域及途中淋巴结转移的高发生率。
Int J Clin Oncol. 2014;19(3):536-43. doi: 10.1007/s10147-013-0571-4. Epub 2013 Jun 4.
4
Rhabdomyosarcoma of the head and neck: 24 cases and literature review.头颈部横纹肌肉瘤:24 例病例报告及文献复习。
Braz J Otorhinolaryngol. 2010 Jul-Aug;76(4):533-7. doi: 10.1590/S1808-86942010000400020.
5
Differentiating between congenital rhabdomyosarcoma versus fibromatosis of the pediatric tongue.小儿舌部先天性横纹肌肉瘤与纤维瘤病的鉴别
Int J Pediatr Otorhinolaryngol. 2010 Jul;74(7):781-5. doi: 10.1016/j.ijporl.2010.03.057.
6
Rhabdomyosarcoma of the posterior chest wall in a newborn: a case report.新生儿后胸壁横纹肌肉瘤:一例报告
Cases J. 2009 Jul 2;2:6818. doi: 10.4076/1757-1626-2-6818.
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Sclerosing pseudovascular rhabdomyosarcoma-immunohistochemical, ultrastructural, and genetic findings indicating a distinct subtype of rhabdomyosarcoma.硬化性假血管性横纹肌肉瘤——免疫组织化学、超微结构及遗传学研究结果提示为横纹肌肉瘤的一种独特亚型
Virchows Arch. 2006 Nov;449(5):572-8. doi: 10.1007/s00428-006-0282-6. Epub 2006 Oct 3.
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Rhabdomyosarcoma in infants younger than one year old: a report from the Italian Cooperative Group.一岁以下婴儿的横纹肌肉瘤:来自意大利合作组的报告
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Solid tumors in the neonatal period.新生儿期的实体瘤。
Clin Pediatr (Phila). 2003 Jan-Feb;42(1):29-34. doi: 10.1177/000992280304200105.
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Neonatal alveolar rhabdomyosarcoma with skin and brain metastases.新生儿肺泡横纹肌肉瘤伴皮肤和脑转移
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