一种Fab片段与其抗原环孢素复合物的结晶及初步X射线研究。
Crystallization and preliminary X-ray investigation of a complex between a Fab fragment and its antigen, cyclosporin.
作者信息
Altschuh D, Kocher H P, Quesniaux V F, Schmitter D, Van Regenmortel M H, Thierry J C
机构信息
Laboratoire d'Immunochimie, Institut de Biologie Moléculaire et Cellulaire du CNRS, Strasbourg, France.
出版信息
J Mol Biol. 1989 Sep 5;209(1):177-8. doi: 10.1016/0022-2836(89)90181-2.
Preliminary crystallographic data are given for a complex between the cyclic undecapeptide cyclosporin and the Fab fragment of an anti-cyclosporin monoclonal antibody. Crystals of the complex are orthorhombic with space group P2(1)2(1)2(1) and diffract to 2.7 A resolution. The unit cell dimensions are a = 52.6 A, b = 70.2 A and c = 118.4 A. A native data set to 2.7 A resolution has been collected.
给出了环十一肽环孢菌素与抗环孢菌素单克隆抗体Fab片段复合物的初步晶体学数据。该复合物的晶体为正交晶系，空间群为P2(1)2(1)2(1)，衍射分辨率为2.7 Å。晶胞参数为a = 52.6 Å，b = 70.2 Å，c = 118.4 Å。已收集到分辨率为2.7 Å的天然数据集。
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