Räsänen M, Helanterä I, Kalliomäki J, Savikko J, Parry M, Lempinen M
Department of Transplant and Liver Surgery, Helsinki University Hospital, Helsinki, Finland.
Department of Transplant and Liver Surgery, Helsinki University Hospital, Helsinki, Finland.
Transplant Proc. 2017 Jan-Feb;49(1):229-231. doi: 10.1016/j.transproceed.2016.08.043.
Nicotine intoxication is a rare cause of death and can lead to brain death after respiratory arrest and hypoxic-ischemic encephalopathy. To our knowledge, no previous reports regarding organ donation after nicotine intoxication have been described. We present a successful case of kidney donation after brain death caused by subcutaneous nicotine overdose from liquid nicotine from an e-cigarette cartridge in an attempted suicide. Both kidneys were transplanted successfully with immediate graft function, and both recipients were discharged at postoperative day 9 with normal plasma creatinine levels. Graft function has remained excellent in follow-up. This case suggests that kidneys from a donor with fatal nicotine intoxication may be successfully used for kidney transplantation in the absence of other contraindications for donation.
尼古丁中毒是一种罕见的死亡原因，可导致呼吸骤停和缺氧缺血性脑病后发生脑死亡。据我们所知，此前尚无关于尼古丁中毒后器官捐献的报道。我们报告了一例成功的肾脏捐献案例，该案例中一名患者因试图自杀而过量皮下注射电子烟弹中的液态尼古丁导致脑死亡。两个肾脏均成功移植，移植后立即恢复功能，两名受者均在术后第9天出院，血浆肌酐水平正常。随访期间移植肾功能一直良好。该案例表明，在没有其他捐献禁忌证的情况下，来自致命尼古丁中毒供者的肾脏可成功用于肾脏移植。
