Carnevali Luca, Montano Nicola, Statello Rosario, Sgoifo Andrea
Stress Physiology Lab., Department of Neuroscience, University of Parma, Italy.
Department of Clinical Sciences and Community Health, IRCCS Ca' Granda Foundation, Ospedale Maggiore Policlinico, University of Milan, Italy.
Neurosci Biobehav Rev. 2017 May;76(Pt A):144-153. doi: 10.1016/j.neubiorev.2016.11.006. Epub 2017 Jan 16.
Numerous epidemiological studies have demonstrated a close and bidirectional association between depression and cardiovascular disorders (CVD). This comorbidity places a significant burden on individuals and the healthcare system. Not surprisingly, in the last two decades preclinical research in the field of depression and CVD has rapidly progressed. Multiple studies have demonstrated that aspects of human depression/cardiovascular comorbidity can be modeled in rodents exposed to chronic stress paradigms and that a depressive-like syndrome can be induced in rodent models of CVD. This research has provided insights into neural, autonomic, humoral, immune and circulatory mechanisms linking co-occurring mood and CVD. Recent investigations have started to address gender and individual differences in the vulnerability to both disorders and have begun to explore the efficacy of novel pharmacological interventions for the treatment of these comorbid conditions. This review discusses relatively well-established findings and the latest discoveries from rodent models of depression and CVD, with the aim of providing an up-to-date reference which may guide future studies of the relationship between mood and cardiovascular disturbances.
众多流行病学研究表明，抑郁症与心血管疾病（CVD）之间存在密切的双向关联。这种共病给个人和医疗保健系统带来了沉重负担。不出所料，在过去二十年中，抑郁症和心血管疾病领域的临床前研究进展迅速。多项研究表明，人类抑郁症/心血管疾病共病的某些方面可以在暴露于慢性应激范式的啮齿动物中建模，并且在心血管疾病的啮齿动物模型中可以诱发类似抑郁的综合征。这项研究为连接同时出现的情绪和心血管疾病的神经、自主神经、体液、免疫和循环机制提供了见解。最近的研究已经开始探讨性别和个体在对这两种疾病易感性方面的差异，并开始探索新型药物干预治疗这些共病状况的疗效。本综述讨论了抑郁症和心血管疾病啮齿动物模型中相对成熟的发现和最新发现，旨在提供最新参考，以指导未来关于情绪与心血管紊乱之间关系的研究。
