Fang W Y, Zhao H Y
J Tongji Med Univ. 1989;9(2):117-20.
A model was produced for formation of coronary artery thrombosis and development of acute myocardial infarction (AMI) in experimental dogs (n = 8) by injuring endothelium of coronary artery with a steel wire, inserting a copper wire into the lumen, and producing local stenosis with a constrictor. The results showed that ST segment of epicardial ECG began to elevate 15-30 min after handling the coronary artery, platelets aggregation rate and plasma TXB2 increased rapidly, plasma 6-k-PGF1 alpha did not change, platelets cGMP rose continuously, while platelets cAMP rose only at 60 min after handling the coronary artery. Histological findings confirmed the occurrence of artery thrombus and myocardial necrosis. The model may be helpful in investigating the whole process of activation of platelet, thrombogenesis and development of AMI, with the changes in biochemistry, structure, pathophsiology and ECG monitored during the period.
通过用钢丝损伤冠状动脉内皮、将铜丝插入管腔并用收缩器造成局部狭窄，建立了实验犬（n = 8）冠状动脉血栓形成和急性心肌梗死（AMI）发展的模型。结果显示，处理冠状动脉后15 - 30分钟，心外膜心电图ST段开始抬高，血小板聚集率和血浆TXB2迅速升高，血浆6 - k - PGF1α无变化，血小板cGMP持续上升，而血小板cAMP仅在处理冠状动脉后60分钟上升。组织学检查结果证实了动脉血栓形成和心肌坏死的发生。该模型可能有助于研究血小板激活、血栓形成和AMI发展的全过程，并在此期间监测生物化学、结构、病理生理学和心电图的变化。
