Zhao H Y, Fang W Y
Department of Internal Medicine, Tongji Hospital, Tongji Medical University, Wuhan.
Chin Med J (Engl). 1991 Sep;104(9):770-5.
In 16 dogs the endothelium of the left anterior descending coronary artery was injured mechanically. Then a copper wire was inserted into the lumen as a choke of flow and the vessel was slightly compressed from outside by a constrictor. Eight dogs had been treated beforehand with a preparation of flavone extracted from the root of the Chinese medicinal herb Andrographis paniculata (TFAP). In the control group, saline solution was given, the epicardially recorded ST segment started to elevate within 15 minutes, the platelet aggregation rate and the plasma levels of TXB2 increased rapidly, whereas the level of 6-k-PGF1 alpha remained stable. Platelet cGMP rose continuously; however, platelet cAMP rose only at 60 minutes. Histological findings confirmed the occurrence of arterial thrombus and myocardial necrosis. Contrariwise, in the pretreated group there was no elevation of the ST segment, plasma 6-k-PGF1 alpha and platelet cAMP were increased, the production of TXB2 and aggregation of platelets were inhibited, and no thrombus or myocardial infarction was induced. All data suggest that TFAP might promote the synthesis of PGI2, inhibit the production of TXA2, stimulate the synthesis of cAMP in platelets, impede aggregation of platelets, and thereby prevent the formation of thrombi as well as the development of myocardial infarction.
对16只犬的左冠状动脉前降支内皮进行机械损伤。然后将一根铜丝插入管腔作为血流阻塞物，并通过一个收缩器从外部对血管进行轻微压迫。8只犬预先用从中药穿心莲根中提取的黄酮制剂（TFAP）进行了治疗。在对照组中，给予生理盐水，心外膜记录的ST段在15分钟内开始升高，血小板聚集率和TXB2血浆水平迅速升高，而6 - k - PGF1α水平保持稳定。血小板cGMP持续上升；然而，血小板cAMP仅在60分钟时升高。组织学检查结果证实了动脉血栓和心肌坏死的发生。相反，在预处理组中，ST段未升高，血浆6 - k - PGF1α和血小板cAMP升高，TXB2的产生和血小板聚集受到抑制，未诱发血栓或心肌梗死。所有数据表明，TFAP可能促进PGI2的合成，抑制TXA2的产生，刺激血小板中cAMP的合成，阻碍血小板聚集，从而防止血栓形成以及心肌梗死的发展。
