乳腺癌的初始氟脱氧葡萄糖（18F）正电子发射断层扫描-计算机断层扫描（FDG-PET/CT）成像——与原发性肿瘤和局部区域转移的相关性

Initial Fludeoxyglucose (18F) Positron Emission Tomography-Computed Tomography (FDG-PET/CT) Imaging of Breast Cancer - Correlations with the Primary Tumour and Locoregional Metastases.

作者信息

Ayaz Sevin, Gültekin Salih Sinan, Ayaz Ümit Yaşar, Dilli Alper

机构信息

Department of Nuclear Medicine, Mersin State Hospital, Mersin, Turkey.

Department of Nuclear Medicine, Hacettepe University, Kastamonu School of Medicine and Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey.

出版信息

Pol J Radiol. 2017 Jan 6;82:9-16. doi: 10.12659/PJR.899358. eCollection 2017.

DOI:10.12659/PJR.899358

PMID:28105247

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5238949/

Abstract

BACKROUND

We aimed to evaluate initial PET/CT features of primary tumour and locoregional metastatic lymph nodes (LNs) in breast cancer and to look for potential relationships between several parameters from PET/CT.

MATERIAL/METHODS: Twenty-three women (mean age; 48.66±12.23 years) with a diagnosis of primary invasive ductal carcinoma were included. They underwent PET/CT imaging for the initial tumour staging and had no evidence of distant metastates. Patients were divided into two groups. The LABC (locally advanced breast cancer) group included 17 patients with ipsilateral axillary lymph node (LN) metastases. The Non-LABC group consisted of six patients without LN metastases. PET/CT parameters including tumour size, axillary LN size, SUV of ipsilateral axillary LNs (SUV-LN), SUV of primary tumour (SUV-T) and NT ratios (SUV-LN/SUV-T) were compared between the groups. Correlations between the above-mentioned PET/CT parameters in the LABC group as well as the correlation between tumour size and SUV-T within each group were evaluated statistically.

RESULTS

The mean values of the initial PET/CT parameters in the LABC group were significantly higher than those of the non-LABC group (p<0.05). The correlation between tumour size and SUV-T value within both LABC and non-LABC groups was statistically significant (p<0.05). In the LABC group, the correlations between the size and SUV-LN values of metastatic axillary LNs, between tumour size and metastatic axillary LN size, between SUV-T values and metastatic axillary LN size, between SUV-T and SUV-LN values, and between tumour size and SUV-LN values were all significant (p<0.05).

CONCLUSIONS

We found significant correlations between PET/CT parameters of the primary tumour and those of metastatic axillary LNs. Patients with LN metastases had relatively larger primary tumours and higher SUV values.

摘要

背景

我们旨在评估乳腺癌原发肿瘤及局部区域转移淋巴结（LNs）的初始PET/CT特征，并探寻PET/CT的几个参数之间的潜在关系。

材料/方法：纳入23例诊断为原发性浸润性导管癌的女性患者（平均年龄48.66±12.23岁）。她们接受PET/CT成像以进行初始肿瘤分期，且无远处转移证据。患者分为两组。局部晚期乳腺癌（LABC）组包括17例有同侧腋窝淋巴结（LN）转移的患者。非LABC组由6例无LN转移的患者组成。比较两组之间的PET/CT参数，包括肿瘤大小、腋窝LN大小、同侧腋窝LNs的SUV（SUV-LN）、原发肿瘤的SUV（SUV-T）和NT比值（SUV-LN/SUV-T）。对LABC组上述PET/CT参数之间的相关性以及每组内肿瘤大小与SUV-T之间的相关性进行统计学评估。

结果

LABC组初始PET/CT参数的平均值显著高于非LABC组（p<0.05）。LABC组和非LABC组内肿瘤大小与SUV-T值之间的相关性均具有统计学意义（p<0.05）。在LABC组中，转移性腋窝LNs的大小与SUV-LN值之间、肿瘤大小与转移性腋窝LN大小之间、SUV-T值与转移性腋窝LN大小之间、SUV-T与SUV-LN值之间以及肿瘤大小与SUV-LN值之间的相关性均显著（p<0.05）。